[1]赵悦悦,蒋晓宏.血清S100β联合IL-6在新生儿窒息后脑损伤的临床价值[J].医学信息,2022,35(06):112-115.[doi:10.3969/j.issn.1006-1959.2022.06.027]
　ZHAO Yue-yue,JIANG Xiao-hong.Clinical Value of serum S100β Combined with IL-6 in Brain Injury After Neonatal Asphyxia[J].Medical Information,2022,35(06):112-115.[doi:10.3969/j.issn.1006-1959.2022.06.027]
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血清S100β联合IL-6在新生儿窒息后脑损伤的临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年06期
页码:
112-115
栏目:
论著
出版日期:
2022-03-15

文章信息/Info

Title:
Clinical Value of serum S100β Combined with IL-6 in Brain Injury After Neonatal Asphyxia
文章编号:
1006-1959（2022）06-0112-04
作者:
赵悦悦; 蒋晓宏
（安徽医科大学附属巢湖医院新生儿科，安徽 合肥 230000）
Author(s):
ZHAO Yue-yue; JIANG Xiao-hong
(Department of Neonatology,Chaohu Hospital Affiliated to Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
新生儿窒息; 脑损伤; 中枢神经特异蛋白β; 白细胞介素-6; 联合检测
Keywords:
Neonatal asphyxia; Brain injury; Central nervous system specific protein β; Interleukin-6; Combined detection
分类号:
R722.12
DOI:
10.3969/j.issn.1006-1959.2022.06.027
文献标志码:
A
摘要:
目的 检测中枢神经特异蛋白β（S100β）与白细胞介素-6（IL-6）在不同程度窒息新生儿血清中的表达，探讨其与新生儿窒息后脑损伤的相关性。方法 选取2020年7月-2021年8月于安徽医科大学附属巢湖医院NICU治疗的61例窒息新生儿为研究对象，根据出生时的Apgar评分分为轻度窒息组（43例）和重度窒息组（18例）。选取同期健康新生儿49例设为对照组。窒息患儿再根据头颅核磁和振幅整合脑电图检查分为脑损伤组（23例）和非脑损伤组（38例）。比较各组新生儿S100β、IL-6水平。结果 轻度窒息组和重度窒息组血清S100β、IL-6水平高于对照组，且重度窒息组高于轻度窒息组，差异有统计学意义（P＜0.05）；脑损伤组S100β、IL-6水平高于非脑损伤组，差异有统计学意义（P＜0.05）；回归分析显示，S100β、IL-6是新生儿脑损伤的影响因素（P＜0.05）；S100β、IL-6及二者联合检测预测窒息后脑损伤的AUC分别为0.928、0.902、0.962；联合检测的敏感度（91.30%）高于S100β（82.60%）、IL-6（87.00%）单独检测；特异度（97.40%）高于S100β（92.10%）和IL-6（78.90%）单独检测。结论 血清S100β、IL-6有助于诊断新生儿窒息后脑损伤，且两项指标联合预测的价值较高，对于临床上评估窒息患儿脑损伤具有一定参考价值。
Abstract:
Objective To detect the expression of central nervous specific protein β (S100β) and interleukin-6 (IL-6) in serum of neonates with different degrees of asphyxia, and to explore its correlation with brain injury after neonatal asphyxia.Methods Sixty-one neonates with asphyxia treated in NICU of Chaohu Hospital Affiliated to Anhui Medical University from July 2020 to August 2021 were selected as the research objects, and they were divided into mild asphyxia group (43 cases) and severe asphyxia group (18 cases) according to Apgar score at birth. 49 healthy newborns were selected as control group. Children with asphyxia were further divided into brain injury group (23 cases) and non-brain injury group (38 cases) according to brain magnetic resonance imaging or amplitude-integrated electroencephalography. The levels of S100β and IL-6 in each group were compared.Results The levels of serum S100β and IL-6 in the mild asphyxia group and the severe asphyxia group were higher than those in the control group, and those in the severe asphyxia group were higher than those in the mild asphyxia group, with significant difference (P<0.05). The levels of S100β and IL-6 in the brain injury group were higher than those in the non-brain injury group, and the differences were statistically significant (P<0.05). Regression analysis showed that S100β and IL-6 were the influencing factors of neonatal brain injury (P<0.05). AUCs of S100β, IL-6 and combined detection for predicting brain injury after asphyxia were 0.928, 0.902 and 0.962, respectively. The sensitivity of combined detection (91.30%) was higher than that of S100β (82.60%) and IL-6 (87.00%) alone; the specificity (97.40%) was higher than that of S100β (92.10%) and IL-6 (78.90%).Conclusion Serum S100β and IL-6 are helpful in the diagnosis of brain injury after neonatal asphyxia, and the combined prediction of the two indexes is of high value, which has certain reference value for clinical evaluation of brain injury in children with asphyxia.

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更新日期/Last Update: 1900-01-01