[1]褚春沐.托吡酯联合丙戊酸钠治疗难治性癫痫的效果及对患者不良反应和癫痫发作次数的影响[J].医学信息,2022,35(20):121-123.[doi:10.3969/j.issn.1006-1959.2022.20.032]
　CHU Chun-mu.Effect of Topiramate Combined with Sodium Valproate in Treatment of Refractory Epilepsy and its Influence on Adverse Reactions and Seizure Frequency[J].Journal of Medical Information,2022,35(20):121-123.[doi:10.3969/j.issn.1006-1959.2022.20.032]
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托吡酯联合丙戊酸钠治疗难治性癫痫的效果及对患者不良反应和癫痫发作次数的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
121-123
栏目:
药物与临床
出版日期:
2022-10-15

文章信息/Info

Title:
Effect of Topiramate Combined with Sodium Valproate in Treatment of Refractory Epilepsy and its Influence on Adverse Reactions and Seizure Frequency
文章编号:
1006-1959（2022）20-0121-03
作者:
褚春沐
（佳木斯市中心医院神经内科，黑龙江 佳木斯 154002）
Author(s):
CHU Chun-mu
(Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
托吡酯; 丙戊酸钠; 难治性癫痫; 认知功能
Keywords:
Topiramate; Sodium valproate; Refractory epilepsy; Cognitive function
分类号:
R742.1
DOI:
10.3969/j.issn.1006-1959.2022.20.032
文献标志码:
A
摘要:
目的 研究托吡酯联合丙戊酸钠治疗难治性癫痫的临床效果及对不良反应和对癫痫发作次数的影响。方法 选取2020年6月-2021年6月在我院诊治的70例难治性癫痫患者为研究对象，采用随机数字表法分为对照组和观察组，各35例。对照组采用丙戊酸钠治疗，观察组在对照组基础上给予托吡酯治疗，比较两组治疗效果、癫痫发作次数、认知功能、生活质量及不良反应发生情况。结果 观察组治疗总有效率（94.29%）高于对照组（82.86%）（P＜0.05）；观察组强直-阵挛发作、失神发作、失张力发作次数均小于对照组（P＜0.05）；两组语言智商、操作智商评分均高于治疗前，且观察组高于对照组（P＜0.05）；两组生活质量评分高于治疗前，且观察组高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 托吡酯联合丙戊酸钠治疗难治性癫痫疗效确切，可减少癫痫发作次数，改善患者认知功能，且不会增加不良反应，是一种安全、有效的联合用药方案。
Abstract:
Objective To study the clinical effect of topiramate combined with sodium valproate in the treatment of refractory epilepsy and its effect on adverse reactions and the number of seizures.Methods A total of 70 patients with refractory epilepsy diagnosed and treated in our hospital from June 2020 to June 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 35 cases in each group. The control group was treated with sodium valproate, and the observation group was treated with topiramate on the basis of the control group. The therapeutic effect, number of seizures, cognitive function, quality of life and adverse reactions were compared between the two groups.Results The total effective rate of the observation group (94.29%) was higher than that of the control group (82.86%) (P<0.05). The frequency of tonic-clonic seizures, absence seizures and atonic seizures in the observation group were less than those in the control group (P<0.05). The scores of language IQ and operation IQ in the two groups were higher than those before treatment, and those in the observation group were higher than the control group (P<0.05). The quality of life scores of the two groups were higher than those before treatment, and the observation group was higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Topiramate combined with sodium valproate is effective in the treatment of refractory epilepsy, which can reduce the number of seizures and improve the cognitive function of patients without increasing adverse reactions. It is a safe and effective combination regimen.

参考文献/References:

[1]张薇.托吡酯联合丙戊酸钠治疗儿童癫痫的有效性及安全性[J].中国实用神经疾病杂志,2016,19(18):6-8.[2]张晓青,孙素真,唐洪侠,等.托吡酯联合左乙拉西坦对难治性癫痫患儿脑电活动、免疫球蛋白和生活质量的影响[J].现代生物医学进展,2020,20(18):3537-3540,3591.[3]王小亚.托吡酯联合丙戊酸钠对难治性癫痫患者癫痫发作次数及生活质量的影响[J].中国合理用药探索,2018,15(6):12-14.[4]闫丽敏,代鸣明.托吡酯联合丙戊酸钠治疗难治性癫痫的临床疗效及其对炎性反应和神经递质的影响[J].实用心脑肺血管病杂志,2018,26(2):108-110. [5]范玲,吕晓东.丙戊酸钠缓释片联合托吡酯治疗难治性癫痫临床疗效观察[J].感染、炎症、修复,2020,21(2):113-114.[6]陈建明,鹿滨麒,陶录岭.托吡酯片结合丙戊酸钠用于难治性癫痫治疗中的效果评价[J].国际医药卫生导报,2018,24(8):1227-1229.[7]张华.拉莫三嗪联合丙戊酸钠治疗难治性癫痫部分性发作的临床研究[J].中国临床药理学杂志,2016,32(12):1085-1087.[8]曹化,仲玲玲,居克举,等.拉莫三嗪联合丙戊酸钠治疗青年难治性部分性癫痫的疗效及对认知功能的影响研究[J].脑与神经疾病杂志,2017,25(1):33-37.[9]陈庆贤,陈海,刘丽霞,等.左乙拉西坦与拉莫三嗪治疗丙戊酸无效型成人难治性癫痫部分性发作的效果比较[J].山东医药,2017,57(16):88-90.[10]姚宝珍,黄婷婷,袁昊,等．microＲNA-34a 和 Notch1信号通路在颞叶癫痫模型大鼠海马中的表达及作用机制[J].中华实用儿科临床杂志,2017,32(12):932-935．[11]沈文,陈兰英,谷婕,等.左乙拉西坦对难治性癫痫患者免疫功能及神经细胞因子的影响[J].贵州医科大学学报,2017,42(12):1456-1460．[12]于奇.拉莫三嗪联合丙戊酸钠对脑卒中继发性癫痫患者的治疗效果和安全性研究[J].贵州医药,2018,42(7):823-824.[13]叶章海.奥卡西平联合丙戊酸钠治疗对青年难治性部分性癫痫患者认知功能的影响[J].现代诊断与治疗,2017,28(21):3949-3951. [14]白焕芳.丙戊酸钠联合拉莫三嗪应用于难治性癫痫治疗中的效果观察[J].现代诊断与治疗,2019,30(11):1824-1825. [15]Shngh E,Pillai K K,Mehndir Atta M.Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms[J].Basic Clin Pharmacol Toxicol,2016,115(5):373-378．[16]王小蛰,凌云.拉莫三嗪联合丙戊酸钠治疗癫痫的临床应用[J].实用中西医结合临床,2018,18(8):58-60.[17]刘明月.拉莫三嗪联合丙戊酸钠对癫痫的治疗效果[J].中国卫生工程学,2018,17(3):455-457.[18]田领.拉莫三嗪联合丙戊酸钠治疗对癫痫患儿疗效改善不良事件及预后的影响研究[J].中国实用神经疾病杂志,2016,19(22):103-105. [19]郑淼磊,黄倩.联合用药治疗青年难治性癫痫的疗效分析[J].深圳中西医结合杂志,2019,29(7):96-97. [20]向瑜.拉莫三嗪联合丙戊酸钠对青年难治性癫痫患者认知功能及癫痫发作频率的影响[J].菏泽医学专科学校学报,2020,32(3):4-6.[21]刘梅.醒脑静联合拉莫三嗪、丙戊酸钠治疗老年脑卒中继发性癫痫患者的疗效观察[J].辽宁中医杂志,2017,44(3):551-553.

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更新日期/Last Update: 1900-01-01