[1]吴印林,曾国晋,王庆龙,等.调控牙本质形成相关信号通路的研究现状[J].医学信息,2024,37(07):168-172.[doi:10.3969/j.issn.1006-1959.2024.07.035]
 WU Yin-lin,ZENG Guo-jin,WANG Qing-long,et al.Research Progress of Signaling Pathways on Regulating Dentinogenesis[J].Journal of Medical Information,2024,37(07):168-172.[doi:10.3969/j.issn.1006-1959.2024.07.035]
点击复制

调控牙本质形成相关信号通路的研究现状()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年07期
页码:
168-172
栏目:
综述
出版日期:
2024-04-01

文章信息/Info

Title:
Research Progress of Signaling Pathways on Regulating Dentinogenesis
文章编号:
1006-1959(2024)07-0168-05
作者:
吴印林曾国晋王庆龙
(蚌埠医学院基础医学院1,口腔医学院2,安徽 蚌埠 233000)
Author(s):
WU Yin-linZENG Guo-jinWANG Qing-longet al.
(Department of Basic Medicine1,Department of Stomatology2,Bengbu Medical College,Bengbu 233000,Anhui,China)
关键词:
信号通路成牙本质细胞牙本质
Keywords:
Signaling pathwayOdontoblastDentin
分类号:
R781.3
DOI:
10.3969/j.issn.1006-1959.2024.07.035
文献标志码:
A
摘要:
牙本质是构成牙体的重要硬组织,其形成受到严格的基因遗传调控。掌握这个庞大的基因网络调控系统有利于阐明牙本质发育、再生和修复过程的分子机制,进一步开发牙本质相关疾病的新型研究思路和治疗方式,帮助解决人类的牙齿疾病。针对调控牙本质形成的生长因子、转录因子等信号分子,本综述对于调控牙本质形成的信号通路和基因进行系统总结,以期为牙本质发育研究和疾病治疗提供理论和实验参考。
Abstract:
entin is an important hard tissue of the tooth. Dentinogenesis is strictly under genetic regulation. Mastering this huge network of regulation system is beneficial to elucidate the molecular mechanism of dentin development, regeneration and repair, and further develop novel research ideas and treatment methods for dentin related diseases, which will help to solve some dental diseases. Aiming at the growth factors, transcription factors and other signaling molecules that regulate dentin formation, this review systematically summarizes the signaling pathways and genes that regulate dentin development and provides theoretical and experimental references for dentin development research and disease treatment.

参考文献/References:

[1]Zhao Y,Yuan X,Liu B,et al.Wnt-Responsive Odontoblasts Secrete New Dentin after Superficial Tooth Injury[J].J Dent Res,2018,97(9):1047-1054.[2]Hara M,Horibe K,Mori H,et al.The role of canonical Wnt signaling in dentin bridge formation[J].J Oral Biosci,2021,63(2):199-209.[3]Bae CH,Kim TH,Ko SO,et al.Wntless regulates dentin apposition and root elongation in the mandibular molar[J].J Dent Res,2015,94(3):439-445.[4]Zhang R,Yang G,Wu X,et al.Disruption of Wnt/β-catenin signaling in odontoblasts and cementoblasts arrests tooth root development in postnatal mouse teeth[J].Int J Biol Sci,2013,9(3):228-236.[5]Zaugg LK,Banu A,Walther AR,et al.Translation Approach for Dentine Regeneration Using GSK-3 Antagonists[J].J Dent Res,2020,99(5):544-551.[6]Ma Y,Jing J,Feng J,et al.Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development[J].Development,2021,148(2):dev196360.[7]Yu S,Li J,Zhao Y,et al.Comparative Secretome Analysis of Mesenchymal Stem Cells From Dental Apical Papilla and Bone Marrow During Early Odonto/Osteogenic Differentiation: Potential Role of Transforming Growth Factor-β2[J].Front Physiol,2020,11:41.[8]Stanwick M,Barkley C,Serra R,et al.Tgfbr2 in Dental Pulp Cells Guides Neurite Outgrowth in Developing Teeth[J].Front Cell Dev Biol,2022,10:834815.[9]Snider TN,Louie KW,Zuzo G,et al.Quantification of three-dimensional morphology of craniofacial mineralized tissue defects in Tgfbr2/Osx-Cre mice[J].Oral Sci Int,2021,18(3):193-202.[10]Zhang R,Lin J,Liu Y,et al.Transforming Growth Factor-β Signaling Regulates Tooth Root Dentinogenesis by Cooperation With Wnt Signaling[J].Front Cell Dev Biol,2021,9:687099.[11]Jani P,Liu C,Zhang H,et al.The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis[J].Arch Oral Biol,2018,90:33-39.[12]Liu M,Goldman G,MacDougall M,et al.BMP Signaling Pathway in Dentin Development and Diseases[J].Cells,2022,11(14):2216.[13]Omi M,Kulkarni AK,Raichur A,et al.BMP-Smad Signaling Regulates Postnatal Crown Dentinogenesis in Mouse Molar[J].JBMR Plus,2019,4(2):e10249.[14]Yun CY,Choi H,You YJ,et al.Requirement of Smad4-mediated signaling in odontoblast differentiation and dentin matrix formation[J].Anat Cell Biol,2016,49(3):199-205.[15]Kim TH,Bae CH,Lee JY,et al.Temporo-spatial requirement of Smad4 in dentin formation[J].Biochem Biophys Res Commun,2015,459(4):706-712.[16]Greenblatt MB,Kim JM,Oh H,et al.p38α MAPK is required for tooth morphogenesis and enamel secretion[J].J Biol Chem,2015,290(1):284-295.[17]Cui D,Xiao J,Zhou Y,et al.Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway[J].Cell Prolif,2019,52(6):e12680.[18]Yang J,Ye L,Hui TQ,et al.Bone morphogenetic protein 2-induced human dental pulp cell differentiation involves p38 mitogen-activated protein kinase-activated canonical WNT pathway[J].Int J Oral Sci,2015,7(2):95-102.[19]Zhou N,Li N,Liu J,et al.Persistent Wnt/β-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme[J].Organogenesis,2019,15(1):1-12.[20]Lim D,Wu KC,Lee A,et al.DSPP dosage affects tooth development and dentin mineralization[J].PLoS One,2021,16(5):e0250429.[21]Liang T,Hu Y,Zhang H,et al.Mouse Dspp frameshift model of human dentinogenesis imperfecta[J].Sci Rep,2021,11(1):20653.[22]Jani PH,Gibson MP,Liu C,et al.Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice[J].Matrix Biol,2016,52-54:95-112.[23]Lee HK,Lee DS,Park SJ,et al.Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis[J].J Biol Chem,2014,289(41):28225-28236.[24]Gao S,Zhao YM,Ge LH.Nuclear factor I-C expression pattern in developing teeth and its important role in odontogenic differentiation of human molar stem cells from the apical papilla[J].Eur J Oral Sci,2014,122(6):382-390.[25]Mishima S,Takahashi K,Kiso H,et al.Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice[J].Sci Rep,2021,11(1):13674.[26]Wen Q,Jing J,Han X,et al.Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM[J].J Bone Miner Res,2020,35(11):2252-2264.[27]Li S,Kong H,Yao N,et al.The role of runt-related transcription factor 2 (Runx2) in the late stage of odontoblast differentiation and dentin formation[J].Biochem Biophys Res Commun,2011,410(3):698-704.[28]Han N,Zheng Y,Li R,et al.β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2[J].PLoS One,2014,9(2):e88890.[29]Zhang H,Jiang Y,Qin C,et al.Essential role of osterix for tooth root but not crown dentin formation[J].J Bone Miner Res,2015,30(4):742-746.[30]Bae JM,Clarke JC,Rashid H,et al.Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts[J].J Bone Miner Res,2018,33(6):1126-1140.[31]Yang G,Yuan G,MacDougall M,et al.BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts[J].Sci Rep,2017,7(1):10775.[32]Lee MH,Kwon TG,Park HS,et al.BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2[J].Biochem Biophys Res Commun,2003,309(3):689-694.

相似文献/References:

[1]侯梦月,黄金智,张玲莉.SIRT2及其与子宫内膜癌关系的研究进展[J].医学信息,2019,32(05):31.[doi:10.3969/j.issn.1006-1959.2019.05.012]
 HOU Meng-yue,HUANG Jin-zhi,ZHANG Ling-li.Progress in the Study of SIRT2 and its Relationship with Endometrial Cancer[J].Journal of Medical Information,2019,32(07):31.[doi:10.3969/j.issn.1006-1959.2019.05.012]
[2]袁晓霞,肖 杨,罗瑶敏,等.长链非编码RNA CASC9的靶基因预测及信号通路富集分析[J].医学信息,2022,35(16):7.[doi:10.3969/j.issn.1006-1959.2022.16.002]
 YUAN Xiao-xia,XIAO Yang,LUO Yao-min,et al.Target Gene Prediction and Signal Pathway Enrichment Analysis of Long Non-coding RNA CASC9[J].Journal of Medical Information,2022,35(07):7.[doi:10.3969/j.issn.1006-1959.2022.16.002]
[3]宋 崟,张 科.基于生物信息学方法探究溃疡性结肠炎的关键基因和通路[J].医学信息,2022,35(16):13.[doi:10.3969/j.issn.1006-1959.2022.16.003]
 SONG Yin,ZHANG Ke.Key Genes and Pathways of Ulcerative Colitis Based on Bioinformatics[J].Journal of Medical Information,2022,35(07):13.[doi:10.3969/j.issn.1006-1959.2022.16.003]
[4]崔方强.足细胞上皮间质转分化研究[J].医学信息,2019,32(22):21.[doi:10.3969/j.issn.1006-1959.2019.22.008]
 CUI Fang-qiang.Epithelial Transdifferentiation of Podocytes[J].Journal of Medical Information,2019,32(07):21.[doi:10.3969/j.issn.1006-1959.2019.22.008]
[5]张伟斌,荆国杰.胶质母细胞瘤信号通路的研究[J].医学信息,2019,32(23):33.[doi:10.3969/j.issn.1006-1959.2019.23.009]
 ZHANG Wei-bin,JING Guo-jie.Study on Glioblastoma Signaling Pathway[J].Journal of Medical Information,2019,32(07):33.[doi:10.3969/j.issn.1006-1959.2019.23.009]
[6]王东梅,张展英.小细胞肺癌中信号通路及蛋白相互作用网络分析[J].医学信息,2020,33(01):81.[doi:10.3969/j.issn.1006-1959.2020.01.025]
 WANG Dong-mei,ZHANG Zhan-ying.Analysis of Signal Pathways and Protein Interaction Networks in Small Cell Lung Cancer[J].Journal of Medical Information,2020,33(07):81.[doi:10.3969/j.issn.1006-1959.2020.01.025]
[7]焦 乐.PEBP4蛋白在复发性脑胶质瘤患者中的表达情况及临床意义分析[J].医学信息,2020,33(08):131.[doi:10.3969/j.issn.1006-1959.2020.08.042]
 JIAO Le.Expression and Clinical Significance of PEBP4 Protein in Patients with Recurrent Glioma[J].Journal of Medical Information,2020,33(07):131.[doi:10.3969/j.issn.1006-1959.2020.08.042]
[8]魏 晨,蒋 振.长链非编码RNA-Hexokinase 2的生物信息学分析[J].医学信息,2022,35(19):1.[doi:10.3969/j.issn.1006-1959.2022.19.001]
 WEI Chen,JIANG Zhen.Bioinformatics Analysis of Long Non-coding RNA-Hexokinase 2[J].Journal of Medical Information,2022,35(07):1.[doi:10.3969/j.issn.1006-1959.2022.19.001]
[9]袁晓霞,蒋 振.长链非编码RNA-Keratin 8的调控通路分析[J].医学信息,2022,35(19):6.[doi:10.3969/j.issn.1006-1959.2022.19.002]
 YUAN Xiao-xia,JIANG Zhen.Regulatory Pathway Analysis of Long Non-coding RNA-Keratin 8[J].Journal of Medical Information,2022,35(07):6.[doi:10.3969/j.issn.1006-1959.2022.19.002]
[10]朱明明,李占全,崔 森.MMP-9信号通路调控乳腺癌发展的机制[J].医学信息,2020,33(13):22.[doi:10.3969/j.issn.1006-1959.2020.13.007]
 ZHU Ming-ming,LI Zhan-quan,CUI Sen.Mechanism of MMP-9 Signaling Pathway Regulating Breast Cancer Development[J].Journal of Medical Information,2020,33(07):22.[doi:10.3969/j.issn.1006-1959.2020.13.007]

更新日期/Last Update: 1900-01-01