[1]赵 慧,巩林霞,魏兆丽,等.脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性[J].医学信息,2022,35(16):109-111.[doi:10.3969/j.issn.1006-1959.2022.16.026]
　ZHAO Hui,GONG Lin-xia,WEI Zhao-li,et al.Expression of Lipid Metabolism Indexes in Type 2 Diabetic Nephropathy and its Correlation with Urinary Albumin[J].Journal of Medical Information,2022,35(16):109-111.[doi:10.3969/j.issn.1006-1959.2022.16.026]
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脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
109-111
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
Expression of Lipid Metabolism Indexes in Type 2 Diabetic Nephropathy and its Correlation with Urinary Albumin
文章编号:
1006-1959（2022）16-0109-03
作者:
赵 慧; 巩林霞; 魏兆丽; 等
（滨州市中心医院内分泌科，山东 滨州 251700）
Author(s):
ZHAO Hui; GONG Lin-xia; WEI Zhao-li; et al.
(Department of Endocrinology,Binzhou Central Hospital,Binzhou251700,Shandong, China)
关键词:
2型糖尿病; 尿白蛋白排泄率; 脂代谢紊乱; 糖尿病肾病
Keywords:
Type 2 diabetes mellitus; Urinary albumin excretion rate; Lipid metabolism disorder; Diabetic nephropathy
分类号:
R587.2；R277.5；
DOI:
10.3969/j.issn.1006-1959.2022.16.026
文献标志码:
A
摘要:
目的 探究与分析脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性。方法 回顾性分析我院自2020 年1月-2021年5月收治的2型糖尿病肾病患者108例的临床资料，按照不同尿白蛋白排泄率（UAER）水平分为微量白蛋白尿组（n=39）、正常白蛋白尿组（n=32）、大量白蛋白尿组（n=37），比较三组一般资料、脂代谢相关指标，同时采用Pearson相关性对2型糖尿病患者不同UAER水平与脂代谢异常的相关性。结果 微量白蛋白尿组、大量白蛋白尿组甘油三酯、总胆固醇、低密度脂蛋白水平高于正常白蛋白尿组，高密度脂蛋白水平低于正常白蛋白尿组，差异有统计学意义（P＜0.05）；大量白蛋白尿组甘油三酯、总胆固醇、低密度脂蛋白水平高于微量白蛋白尿组，高密度脂蛋白水平低于微量白蛋白尿组，差异有统计学意义（P＜0.05）；Pearon相关性分析可见，UAER与甘油三酯、总胆固醇、低密度脂蛋白呈正相关（r=0.458、0.551、0.658，P＜0.05），与高密度脂蛋白呈负相关（r=-0.325，P＜0.05）。结论 随着UAER水平的升高，甘油三酯、总胆固醇、低密度脂蛋白也呈现出升高的趋势，但高密度脂蛋白呈现出降低的趋势。
Abstract:
Objective To explore and analyze the expression level of lipid metabolism index in type 2 diabetic nephropathy and its correlation with urinary albumin.Methods The clinical data of 108 patients with type 2 diabetic nephropathy admitted to our hospital from January 2020 to May 2021 were retrospectively analyzed. According to different urinary albumin excretion rate (UAER) levels, they were divided into microalbuminuria group (n=39), normal albuminuria group (n=32) and massive proteinuria group (n=37). The general data and lipid metabolism related indexes of the three groups were compared. At the same time, the correlation between different UAER levels and abnormal lipid metabolism in patients with type 2 diabetes mellitus was analyzed by Pearson correlation.Results The levels of triglyceride, total cholesterol and low-density lipoprotein in microalbuminuria group and massive proteinuria group were higher than those in normal proteinuria group, and the level of high-density lipoprotein was lower than that in normal proteinuria group, the difference was statistically significant (P<0.05). The levels of triglyceride, total cholesterol and low-density lipoprotein in the massive proteinuria group were higher than those in the microalbuminuria group, and the level of high-density lipoprotein was lower than that in the microalbuminuria group, the difference was statistically significant (P<0.05). Pearon correlation analysis showed that UAER was positively correlated with triglyceride, total cholesterol and low density lipoprotein (r=0.458, 0.551, 0.658, P<0.05), and negatively correlated with high density lipoprotein (r=-0.325, P<0.05).Conclusion With the increase of UAER level, triglyceride, total cholesterol and low density lipoprotein also show an increasing trend, but high density lipoprotein shows a decreasing trend.

参考文献/References:

[1]邱楚雄,唐立明,覃娜,等.坤草芪莲汤治疗糖尿病尿微量白蛋白症并脂代谢异常疗效观察[J].现代中西医结合杂志,2019,29(35):3887-3890.[2]鞠建南,裴淑桥,王瑾,等.2型糖尿病肾病患者中性粒细胞/淋巴细胞比值与肾功能的相关性研究[J].标记免疫分析与临床,2020,27(11):1907-1910.[3]赵俐丽,叶山东,陈超,等.1型糖尿病患者血脂与糖尿病肾脏疾病的关系[J].中国临床保健杂志,2019,22(2):264-266.[4]郭久畅,张琳,杨丹,等.超重或肥胖男性2型糖尿病患者血清25羟维生素D水平与微量白蛋白尿的相关性研究[J].中国全科医学,2020,23(15):1884-1885.[5]中华医学会糖尿病学分会,国家基层糖尿病防治管理办公室.国家基层糖尿病防治管理指南(2018)[J].中华内科杂志,2018,57(12):885-893.[6]中华医学会糖尿病学分会,中华医学会糖尿病学分会微血管并发症学组.糖尿病肾病防治专家共识(2014年版)[J].中华糖尿病杂志,2014,6(11):792-801.[7]陈小红,杨渝伟,彭玲,等.肾损伤和脂质异常与非清蛋白尿DKD发生的关系[J].重庆医学,2020,49(8):1205-1211.[8]陶瑜,李建婷,胡晓琳,等.脂代谢与2型糖尿病肾病蛋白尿的相关性[J].潍坊医学院学报,2019,41(2):151-154.[9]朱荔,丘红梅.中老年2型糖尿病患者血清尿酸与糖脂代谢的相关性[J].大理大学学报,2020,5(4):73-77.[10]石一夫,张焱,王奕,等.2型糖尿病合并冠心病患者血清miR-21、miR-155水平与脂代谢的关系[J].心血管康复医学杂志,2019,28(4):416-423.[11]张露露,胡晓燕,王玉忠,等.初诊2型糖尿病患者正常水平促甲状腺激素与糖脂代谢相关分析[J].智慧健康,2019,5(33):7-8.[12]朱维维.2型糖尿病患者脂代谢异常对骨质疏松发生的影响分析[J].医学研究,2019,1(4):197-198.[13]李廷灿,叶瑞航,叶宏平.短期胰岛素泵强化治疗对2型糖尿病患者血糖、血脂水平及胰岛β细胞功能的影响[J].慢性病学杂志,2021,22(5):729-731.[14]王锋,柳和春,刘小松.不同来源ω-3多不饱和脂肪酸对2型糖尿病合并血脂异常人群糖脂代谢的影响[J].中华预防医学杂志,2019,53(6):570-575.[15]赵帆,王艳,李文杰.血清维生素D水平与2型糖尿病患者糖脂代谢指标的相关性[J].河南医学研究,2019,28(5):789-792.[16]杨军,姚明瑞,马东红,等.糖尿病肾病患者血清糖原合酶激酶-3β水平与尿微量白蛋白的相关性分析[J].中国临床医学杂志,2020,48(5):542-545.[17]张彤,凌宏威,应长江,等.沙格列汀联合缬沙坦对早期2型糖尿病肾病患者炎性指标与肾功能的影响[J].疑难病杂志,2020,19(4):353-357.[18]许瑶,胡天晓,谭擎缨,等.2型糖尿病慢性肾病1期患者肾小球滤过率与腹内脂肪面积的相关性研究[J].浙江医学,2020,42(21):2313-2316.[19]陈燕,钟静,董加宝.尿微量白蛋白联合血清碱性磷酸酶、胱抑素C水平与早期2型糖尿病肾病的相关性研究[J].中国医刊,2020,55(7):740-743.[20]张盈莹,卓永,欧佩,等.尿NGAL及KIM-1水平对藏区糖尿病肾脏病的临床诊断价值研究[J].国际内分泌代谢杂志,2020,40(5):294-299.

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更新日期/Last Update: 1900-01-01