[1]徐 雨,朱耀峰,李 萍.2型糖尿病周围神经病变患者震动感觉阈值与糖化血红蛋白的相关性研究[J].医学信息,2025,38(03):113-117.[doi:10.3969/j.issn.1006-1959.2025.03.021]
　XU Yu,ZHU Yaofeng,LI Ping.Study on the Correlation Between Vibration Perception Threshold and Glycosylated Hemoglobin in Patients with Type 2 Diabetic Peripheral Neuropathy[J].Journal of Medical Information,2025,38(03):113-117.[doi:10.3969/j.issn.1006-1959.2025.03.021]
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2型糖尿病周围神经病变患者震动感觉阈值与糖化血红蛋白的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年03期
页码:
113-117
栏目:
论著
出版日期:
2025-02-01

文章信息/Info

Title:
Study on the Correlation Between Vibration Perception Threshold and Glycosylated Hemoglobin in Patients with Type 2 Diabetic Peripheral Neuropathy
文章编号:
1006-1959（2025）03-0113-05
作者:
徐 雨1; 朱耀峰1; 李 萍2
1.吉首大学医学院，湖南 吉首 416000；2.湘西土家族苗族自治州民族中医院科教科，湖南 吉首 416000
Author(s):
XU Yu1;  ZHU Yaofeng1;  LI Ping2
1.Jishou University School of Medicine, Jishou 416000, Hunan, China;2.Science and Education Department of Xiangxi Tujia and Miao Autonomous Prefecture Minzu Traditional Chinese Medicine Hospital, Jishou 416000, Hunan, China
关键词:
2型糖尿病; 周围神经病变; 糖化血红蛋白; 震动感觉阈值; 相关性分析
Keywords:
Type 2 diabetes mellitus;  Peripheral neuropathy;  Glycosylated hemoglobin;  Vibration perception threshold;  Correlation analysis
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2025.03.021
文献标志码:
A
摘要:
目的 探讨2型糖尿病（T2DM）患者震动感觉阈值（VPT）与糖化血红蛋白的相关性，分析T2DM周围神经病变的病理生理机制。方法 回顾性分析2022年1月-2024年1月在湘西土家族苗族自治州民族中医院诊治的T2DM患者的临床资料。采用数字震动感觉阈值检查仪对纳入患者进行VPT检测，将患者分为糖尿病组（n=111）、VPT减退组（n=160）和VPT缺失组（n=142）。收集患者基线资料，检测空腹血糖、餐后2 h血糖、谷丙转氨酶（ALT）、谷草转氨酶（AST）、尿素氮（BUN）、血肌酐（Cr）和糖化血红蛋白（HbA1c）。随后进行统计学分析和相关性矩阵图绘制，使用Spearman相关性分析探讨HbA1c及相关指标与VPT的相关性。结果 单因素分析显示血Cr、HbA1c是影响T2DM周围神经病变的危险因素（P＜0.05），年龄、T2DM病程、BMI、空腹血糖、餐后2 h血糖、ALT、AST、BUN比较，差异无统计学意义（P＞0.05）。Spearman相关性分析表明，BMI、空腹血糖、AST、ALT以及HbA1c与VPT呈正相关，而年龄、糖尿病病程、餐后2 h血糖、BUN和血Cr与VPT呈负相关（P＜0.05）。回归分析进一步证实了HbA1c与VPT呈显著正相关关系（P＜0.01）。结论 糖尿病周围神经病变受BMI、空腹血糖、AST、ALT影响，且HbA1c与VPT存在相关性。
Abstract:
Objective To investigate the correlation between vibration perception threshold (VPT) and glycosylated hemoglobin in patients with type 2 diabetes mellitus (T2DM), and to analyze the pathophysiological mechanism of peripheral neuropathy in T2DM. Methods The clinical data of patients with T2DM diagnosed and treated in the Xiangxi Tujia and Miao Autonomous Prefecture Minzu Traditional Chinese Medicine Hospital from January 2022 to January 2024 were retrospectively analyzed. The patients were divided into diabetes group (n=111), VPT decrease group (n=160) and VPT deficiency group (n=142). The baseline data of patients were collected, and fasting blood glucose, 2 h postprandial blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN), serum creatinine (Cr) and glycosylated hemoglobin (HbA1c) were detected. Subsequently, statistical analysis and correlation matrix mapping were performed, and Spearman correlation analysis was used to explore the correlation between HbA1c and related indicators and VPT. Results Univariate analysis showed that blood Cr and HbA1c were risk factors for peripheral neuropathy in T2DM (P<0.05), while there was no significant difference in age, course of T2DM, BMI, fasting blood glucose, 2 h postprandial blood glucose, ALT, AST and BUN (P>0.05). Spearman correlation analysis showed that BMI, fasting blood glucose, AST, ALT and HbA1 c were positively correlated with VPT, while age, duration of diabetes, postprandial 2 h blood glucose, BUN and blood Cr were negatively correlated with VPT (P<0.05). Regression analysis further confirmed that there was a significant positive correlation between HbA1c and VPT (P<0.01). Conclusion Diabetic peripheral neuropathy is affected by BMI, fasting blood glucose, AST and ALT, and there is a correlation between HbA1c and VPT.

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更新日期/Last Update: 1900-01-01