[1]汪 奇,刘尚全,蒋俊兰.非高密度脂蛋白与2型糖尿病患者亚临床动脉粥样硬化的相关性分析[J].医学信息,2021,34(04):106-109.[doi:10.3969/j.issn.1006-1959.2021.04.028]
　WANG Qi,LIU Shang-quan,JIANG Jun-lan.Correlation Analysis of Non-high-density Lipoprotein and Subclinical Atherosclerosis in Patients with Type 2 Diabetes[J].Medical Information,2021,34(04):106-109.[doi:10.3969/j.issn.1006-1959.2021.04.028]
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非高密度脂蛋白与2型糖尿病患者亚临床动脉粥样硬化的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
106-109
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Correlation Analysis of Non-high-density Lipoprotein and Subclinical Atherosclerosis in Patients with Type 2 Diabetes
文章编号:
1006-1959（2021）04-0106-04
作者:
汪 奇; 刘尚全; 蒋俊兰
（安徽医科大学第三附属医院/合肥市第一人民医院内分泌科，安徽 合肥 230000）
Author(s):
WANG Qi; LIU Shang-quan; JIANG Jun-lan
(Department of Endocrinology,the Third Affiliated Hospital of Anhui Medical University/Hefei First People’s Hospital, Hefei 230000,Anhui,China)
关键词:
2型糖尿病; 亚临床动脉粥样硬化; 颈动脉内中膜厚度; 颈动脉斑块
Keywords:
Type 2 diabetes; Subclinical atherosclerosis; Carotid artery intima-media thickness;  Carotid artery plaque
分类号:
R587.2；R543.4
DOI:
10.3969/j.issn.1006-1959.2021.04.028
文献标志码:
A
摘要:
目的 探讨非高密度脂蛋白（非HDLC）等血脂指标与2型糖尿病患者亚临床动脉粥样硬化（As）的相关性，为2型糖尿病患者进行大血管并发症的防治提供参考依据。方法 选取2010年1月~2016年12月合肥市第一人民医院内分泌科收治的2型糖尿病患者2193例，通过颈动脉超声测量双侧颈动脉内中膜厚度（CIMT）和斑块，根据彩超结果将患者分为正常组（809例）、中膜增厚组（223例）和斑块组（1161例），比较三组年龄、性别、吸烟史、脂肪肝等临床资料和血糖、血脂等生化指标的差异，将中膜增厚或斑块形成合并为亚临床动脉粥样硬化组，采用二元Logistic回归分析As的影响因素。结果 斑块组吸烟人数、糖尿病家族史人数、脂肪肝人数、年龄、病程、BMI、收缩压、尿素氮、血肌酐、血尿酸、非HDLC、TC、LDLC/HDLC、LDLC均高于正常组，差异有统计学意义（P＜0.05）；中膜增厚组年龄、病程、BMI、收缩压、尿素氮、非HDLC/HDLC高于正常组，差异有统计学意义（P＜0.05）。二元Logistic回归分析显示，年龄（OR=1.110，95%CI：1.095~1.125）、病程（OR=1.003，95%CI：1.001~1.004）、收缩压（OR=1.008，95%CI：1.002~1.015）、非HDLC（OR=1.203，95%CI：1.077~1.343）是As的独立危险因素，HDLC（OR=0.073，95%CI：0.538~0.972）是As的保护因素。结论 非HDLC是评价2型糖尿病患者发生亚临床动脉粥样硬化的良好指标。
Abstract:
Objective To explore the relationship between non-high-density lipoprotein (non-HDLC) and other blood lipid indicators and subclinical atherosclerosis (As) in type 2 diabetes patients, and provide a reference for the prevention and treatment of macrovascular complications in type 2 diabetes patients.Methods A total of 2193 patients with type 2 diabetes who were admitted to the Department of Endocrinology, Hefei First People’s Hospital from January 2010 to December 2016 were selected to measure bilateral carotid artery intima-media thickness (CIMT) and plaques by carotid ultrasound.According to the results of color Doppler ultrasound, the patients were divided into normal group (809 cases), media thickening group (223 cases) and plaque group (1161 cases).Compare the differences in clinical data such as age, gender, smoking history, fatty liver, and biochemical indicators such as blood sugar and blood lipids among the three groups,the media thickening or plaque formation was combined into the subclinical atherosclerosis group, and the influencing factors of As were analyzed by binary Logistic regression.Results The number of smokers in the plaque group, the number of people with family history of diabetes, the number of fatty livers, age, course of disease, BMI, systolic blood pressure, urea nitrogen, blood creatinine, blood uric acid, non-HDLC, TC, LDLC/HDLC, and LDLC were all higher than the normal group,the difference was statistically significant (P＜0.05);The age, course of disease, BMI, systolic blood pressure, urea nitrogen, non-HDLC/HDLC in the thickened media group were higher than those in the normal group,the difference was statistically significant (P<0.05).Binary Logistic regression analysis showed that age (OR=1.110, 95%CI: 1.095~1.125), course of disease (OR=1.003, 95%CI: 1.001~1.004), systolic blood pressure (OR=1.008, 95%CI: 1.002~ 1.015), non-HDLC (OR=1.203, 95%CI: 1.077~1.343)were independent risk factors for As,HDLC (OR=0.073, 95%CI: 0.538~0.972) was the protective factor of As.Conclusion Non-HDLC is a good indicator for evaluating subclinical atherosclerosis in patients with type 2 diabetes.

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更新日期/Last Update: 1900-01-01