[1]杨 丹,江毅敏,周小燕,等.不同空腹血糖状态与外周血NLR、LMR、PLR及MHR的相关性研究[J].医学信息,2022,35(04):107-110.[doi:10.3969/j.issn.1006-1959.2022.04.026]
　YANG Dan,JIANG Yi-min,ZHOU Xiao-yan,et al.Study on the Correlation Between Different Fasting Glucose Status and Peripheral BloodNLR, LMR, PLR and MHR[J].Medical Information,2022,35(04):107-110.[doi:10.3969/j.issn.1006-1959.2022.04.026]
点击复制

不同空腹血糖状态与外周血NLR、LMR、PLR及MHR的相关性研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年04期
页码:
107-110
栏目:
论著
出版日期:
2022-02-15

文章信息/Info

Title:
Study on the Correlation Between Different Fasting Glucose Status and Peripheral BloodNLR, LMR, PLR and MHR
文章编号:
1006-1959（2022）04-0107-04
作者:
杨 丹1; 2; 江毅敏1; 2; 周小燕1; 2; 雷 蓉1; 2; 柳 弥1; 2
川北医学院附属医院健康管理中心1，健康管理中心研究室2，四川 南充 637000
Author(s):
YANG Dan1; 2; JIANG Yi-min1; 2; ZHOU Xiao-yan1; 2; LEI Rong; LIU Mi1; 2
Health Management Center1,Laboratory of Health Management Center2,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China
关键词:
空腹血糖; 中性粒细胞/淋巴细胞计数比值; 淋巴细胞/单核细胞计数比值; 血小板/淋巴细胞计数比值; 单核细胞/高密度脂蛋白胆固醇比值
Keywords:
Fasting blood glucose;  Neutrophil-to-lymphocyte ratio; Lymphocyte-to-MONOCYTE Ratio; Platelet-to-lymphocyte ratio; Monocyte-to-high density lipoprotein cholesterol ratio
分类号:
R587
DOI:
10.3969/j.issn.1006-1959.2022.04.026
文献标志码:
A
摘要:
目的 探讨健康体检人群中不同空腹血糖状态与外周血中性粒细胞/淋巴细胞计数比值（NLR）、淋巴细胞/单核细胞计数比值（LMR）、血小板/淋巴细胞计数比值（PLR）、单核细胞/高密度脂蛋白胆固醇比值（MHR）的相关性。方法 选取2020年1月-10月川北医学院附属医院健康管理中心进行健康体检的人群5754例作为研究对象，根据空腹血糖水平（FPG）分为正常空腹血糖组（NG组）、空腹血糖受损组（IFG组）和高空腹血糖组（HFG组），比较三组一般资料、临床生化指标，采用二元Logistic回归分析影响空腹血糖受损的因素。结果 5754例研究对象中检出正常空腹血糖5242例，占91.10%；空腹血糖受损198例，占3.44%；高空腹血糖314例，占5.46%。三组间性别、年龄、体质量指数（BMI）、腰臀比（WHR）、收缩压（SBP）、舒张压（DBP）、糖化血红蛋白（HbA1c）、门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、尿素（Ur）、肾小球滤过率估算值（eGFR）、尿酸（UA）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、极低密度脂蛋白胆固醇（VLDL-C）、NLR、LMR、PLR、MHR比较，差异有统计学意义（P＜0.05）；二元Logistic回归分析显示，SBP、HbA1c、LMR、PLR、MHR、TC、HDL-C是空腹血糖受损的危险因素（P＜0.05）。结论 不同空腹血糖状态与外周血中NLR、LMR、PLR、MHR密切相关，同时SBP、HbA1c、TC、HDL-C也是影响空腹血糖受损的危险因素。
Abstract:
Objective To investigate the correlation between different fasting blood glucose status and the neutrophil-to-lymphocyte ratio(NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-high density lipoprotein cholesterol ratio (MHR)in peripheral blood.Methods A total of 5754 normal people who underwent a physical examination in the Health Management Center of the Affiliated Hospital of North Sichuan Medical College from January to October 2020 were selected as the research objects. According to the fasting blood glucose level (FPG), they were divided into a normal fasting blood glucose group (NG group), impaired fasting blood glucose group (IFG group) and high fasting blood glucose group (HFG group). The general data and clinical biochemical indexes of the three groups were compared. Binary Logistic regression analysis was used to analyze the factors affecting fasting blood glucose damage.Results Among 5754 cases, 5242 cases of normal fasting blood glucose were detected, accounting for 91.10%; 198 cases of impaired fasting blood glucose, accounting for 3.44%; high fasting blood glucose in 314 cases, accounting for 5.46%. There were statistically significant differences in gender, age, body mass index (BMI), waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycosylated hemoglobin (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea (Ur), estimated glomerular filtration rate (eGFR), uric acid (UA), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), NLR, LMR, PLR and MHR among the three groups (P<0.05). Binary Logistic regression analysis showed that SBP, HbA1c, LMR, PLR, MHR, TC and HDL-C were risk factors for impaired fasting blood glucose (P<0.05).Conclusion NLR,LMR, PLR and MHR in peripheral blood are correlated with different fasting blood glucose status. At the same time, SBP, HbA1c, TC and HDL-C are also risk factors affecting fasting blood glucose level.

参考文献/References:

[1]Nordmann TM,Dror E,Schulze F,et al.The Role of Inflammation in β-cell Dedifferentiation[J].Scientific Reports,2017,7(1):6285.[2]Tahrani AA,Barnett AH,Bailey CJ.Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus[J].Nature Reviews Endocrinology,2016,12(10):566-592.[3]曹润泽,李雪锋.中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、淋巴细胞/单核细胞比值与2型糖尿病肾病患者肾功能的相关性研究[J].临床内科杂志,2020,37(7):508-510.[4]Ya G,Qiu Z,Tianrong P.Relation of Monocyte/High-Density Lipoprotein Cholesterol Ratio with Coronary Artery Disease in Type 2 Diabetes Mellitus[J].Clinical Laboratory,2018,64(6):901-906.[5]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):4-67.[6]Unnikrishnan R,Pradeepa R,Joshi SR,et al.Type 2 Diabetes: Demystifying the Global Epidemic[J].Diabetes,2017,66(6):1432-1442.[7]Khan RMM,Chua ZJY,Tan JC,et al.From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research[J].Medicina (Kaunas),2019,55(9):546.[8]靳育静,高鹰,张卿.空腹血糖正常体检人群餐后血糖异常的危险因素分析[J].中华健康管理学杂志,2020,14(3):260-264.[9]Karam BS,Chavez-Moreno A,Koh W,et al.Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes[J].Cardiovasc Diabetol,2017,16(1):120.[10]侯丹丹.中性粒细胞/淋巴细胞比值与代谢综合征的相关性分析[D].银川:宁夏医科大学,2019. [11]石灵.中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值与冠心病合并糖尿病的相关性研究[D].广州:南方医科大学,2018.[12]Odegaard AO,Jacobs DR Jr,Sanchez OA,et al.Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes[J].Cardiovasc Diabetol,2016(15):51.[13]丘如,黄贵心.血炎性指标NLR、PLR及MHR与糖尿病性心肌病的相关性研究[J].国际内分泌代谢杂志,2020,40(6):367-371. [14]赵瑛,李晓龙,周立新,等.NLR及PLR对老年2型糖尿病患者合并心功能不全的预测价值[J].中国老年学杂志,2020,40(4):682-685.[15]Ya G,Qiu Z,Tianrong P.Relation of Monocyte/High-Density Lipoprotein Cholesterol Ratio with Coronary Artery Disease in Type 2 Diabetes Mellitus[J].Clinical Laboratory,2018,64(6):901-906. [16]马晓云.中性粒细胞/淋巴细胞水平与2型糖尿病及其动脉粥样硬化的研究[J].医学信息,2021,34(18):47-49.[17]张晓畅,吕跃斌,周锦辉,等.中国9个长寿地区65岁及以上人群中性粒细胞与淋巴细胞比值与抑郁症状的关联研究[J].中华预防医学杂志,2021,55(1):25-30.[18]Kitada M,Ogura Y,Monno I,et al.Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function[J].Front Endocrinol (Lausanne),2019(10):187.[19]Poznyak A,Grechko AV,Poggio P,et al.The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation[J].Int J Mol Sci,2020,21(5):1835.[20]蒋唯薇,彭年春,时立新,等.2017年ACC/AHA高血压指南对贵阳城区40~79岁不同糖代谢状态人群高血压患病情况的可能影响[J].中华内分泌代谢杂志,2020(3):220-226.[21]Wang JR,Chen Z,Yang K,et al.Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history[J].Diabetology and Metabolic Syndrome,2020,12(1):412-418.

相似文献/References:

[1]刘志新,刘志奎,张 越,等.腰椎PLF术后空腹血糖变化研究[J].医学信息,2018,31(16):72.[doi:10.3969/j.issn.1006-1959.2018.16.020]
　LIU Zhi-xin,LIU Zhi-kui,ZHANG Yue,et al.Changes of Fasting Blood Glucose after Lumbar PLF Operation[J].Medical Information,2018,31(04):72.[doi:10.3969/j.issn.1006-1959.2018.16.020]
[2]叶 军,邹玲玲,戴 武,等.社区慢病管理对2型糖尿病患者糖化血红蛋白的影响[J].医学信息,2018,31(19):99.[doi:10.3969/j.issn.1006-1959.2018.19.029]
　YE Jun,ZOU Ling-ling,DAI Wu,et al.Effects of Community Chronic Disease Management on Glycosylated Hemoglobin in Patients with Type 2 Diabetes Mellitus[J].Medical Information,2018,31(04):99.[doi:10.3969/j.issn.1006-1959.2018.19.029]
[3]李 荣,余结根,张斌华,等.芜湖地区中青年人群空腹血糖和糖化血红蛋白的相关性[J].医学信息,2020,33(07):127.[doi:10.3969/j.issn.1006-1959.2020.07.040]
　LI Rong,YU Ji-gen,ZHANG Bin-hua,et al.Correlation Between Fasting Blood Glucose and Glycated Hemoglobin in Middle-aged and Young People in Wuhu Area[J].Medical Information,2020,33(04):127.[doi:10.3969/j.issn.1006-1959.2020.07.040]
[4]黄 婷,徐 燕,史庆星.2型糖尿病患者糖化血红蛋白与空腹血糖、血脂检测的关系分析[J].医学信息,2022,35(18):147.[doi:10.3969/j.issn.1006-1959.2022.18.041]
　HUANG Ting,XU Yan,SHI Qing-xing.Analysis of the Relationship Between Glycosylated Hemoglobin and Fasting Blood Glucose,Blood Lipids in Patients with Type 2 Diabetes Mellitus[J].Medical Information,2022,35(04):147.[doi:10.3969/j.issn.1006-1959.2022.18.041]
[5]孙秀梅,张 蝶.糖化血红蛋白联合空腹血糖检测在妊娠期糖尿病筛查中的应用[J].医学信息,2020,33(11):171.[doi:10.3969/j.issn.1006-1959.2020.11.056]
　SUN Xiu-mei,ZHANG Die.Application of Glycated Hemoglobin Combined with Fasting Blood Glucose Detection in Gestational Diabetes Screening[J].Medical Information,2020,33(04):171.[doi:10.3969/j.issn.1006-1959.2020.11.056]
[6]葛 敏,屈晓冰.NLR及hs-CRP水平与高血压病患者动态血压负荷的相关性分析[J].医学信息,2020,33(21):79.[doi:10.3969/j.issn.1006-1959.2020.21.023]
　GE Min,QU Xiao-bing.Correlation Analysis Between NLR and hs-CRP Levels and Ambulatory Blood Pressure Load in Patients with Hypertension[J].Medical Information,2020,33(04):79.[doi:10.3969/j.issn.1006-1959.2020.21.023]
[7]高艳红,哈海枫,陈小军,等.甘精胰岛素联合瑞格列奈治疗老年2型糖尿病的临床效果[J].医学信息,2021,34(01):152.[doi:10.3969/j.issn.1006-1959.2021.01.041]
　GAO Yan-hong,HA Hai-feng,CHEN Xiao-jun,et al.Clinical Effect of Insulin Glargine Combined with Repaglinide in the Treatment of Elderly Type 2 Diabetes[J].Medical Information,2021,34(04):152.[doi:10.3969/j.issn.1006-1959.2021.01.041]
[8]雷 锐,李 志.肌钙蛋白与心肌酶谱联合诊断冠心病的价值[J].医学信息,2022,35(22):154.[doi:10.3969/j.issn.1006-1959.2022.22.038]
　LEI Rui,LI Zhi.The Value of Combined Diagnosis of Cardiac Troponin and Myocardial Enzymes in Coronary Heart Disease[J].Medical Information,2022,35(04):154.[doi:10.3969/j.issn.1006-1959.2022.22.038]
[9]白任然,高 亮,姜 力,等.输尿管软镜碎石术后全身炎症反应综合征的危险因素分析[J].医学信息,2021,34(07):102.[doi:10.3969/j.issn.1006-1959.2021.07.028]
　BAI Ren-ran,GAO Liang,JIANG Li,et al.Analysis of Risk Factors of Systemic Inflammatory Response Syndrome After Flexible Ureteroscope Lithotripsy[J].Medical Information,2021,34(04):102.[doi:10.3969/j.issn.1006-1959.2021.07.028]
[10]凌大军,许映红.不同他汀类药物治疗老年冠心病的疗效比较[J].医学信息,2021,34(18):158.[doi:10.3969/j.issn.1006-1959.2021.18.043]
　LING Da-jun,XU Ying-hong.Comparison of the Efficacy of Different Statins in the Treatment ofCoronary Heart Disease in the Elderly[J].Medical Information,2021,34(04):158.[doi:10.3969/j.issn.1006-1959.2021.18.043]

更新日期/Last Update: 1900-01-01