[1]祝悦悦,张玉珍,曹志瑞,等.孕中期血清维生素D与糖代谢相关性分析[J].医学信息,2022,35(07):109-111.[doi:10.3969/j.issn.1006-1959.2022.07.026]
　ZHU Yue-yue,ZHANG Yu-zhen,CAO Zhi-rui,et al.Relationship Between Vitamin D Level and Glucose Metabolism in Second Trimester of Pregnancy[J].Medical Information,2022,35(07):109-111.[doi:10.3969/j.issn.1006-1959.2022.07.026]
点击复制

孕中期血清维生素D与糖代谢相关性分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年07期
页码:
109-111
栏目:
论著
出版日期:
2022-04-01

文章信息/Info

Title:
Relationship Between Vitamin D Level and Glucose Metabolism in Second Trimester of Pregnancy
文章编号:
1006-1959（2022）07-0109-03
作者:
祝悦悦; 张玉珍; 曹志瑞; 等
（安徽医科大学第三附属医院/合肥市第一人民医院妇产科，安徽 合肥 230061）
Author(s):
ZHU Yue-yue; ZHANG Yu-zhen; CAO Zhi-rui; et al.
(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Anhui Medical University/Hefei First People’s Hospital,Hefei 230061,Anhui,China)
关键词:
维生素D; 糖代谢; 胰岛素抵抗
Keywords:
Vitamin D; Glucose metabolism; Insulin resistance
分类号:
R587
DOI:
10.3969/j.issn.1006-1959.2022.07.026
文献标志码:
A
摘要:
目的 探讨怀孕中期血清维生素D与葡萄糖代谢之间的关系。方法 选择2016年1月1日-2019年12月31日在我院门诊产检，具有完整资料的5690例孕24~28周的孕妇作为研究对象，根据其血清维生素D水平分为维生素D缺乏组4517例和正常组1173例。分析维生素D缺乏与口服葡萄糖耐量试验（OGTT）3项血糖、空腹胰岛素及胰岛素抵抗（HOMA-IR）的关系，以及妊娠期糖尿病的影响因素。结果 维生素D缺乏组空腹葡萄糖水平为（4.60±0.50）mmol/L、空腹胰岛素水平为（8.52±4.13）uU/ml、胰岛素抵抗指数为（1.77±1.01），分别高于正常组的（4.56±0.46）mmol/L、（8.18±4.03）uU/ml及（1.68±0.96），差异有统计学意义（P＜0.05）；线性回归分析表明维生素D缺乏与空腹血糖、空腹胰岛素、胰岛素抵抗指数呈负相关（P＜0.05）；Logistic回归分析显示，维生素D缺乏、高龄、肥胖是妊娠期糖尿病的风险因素（OR=1.184、1.918、2.497，P＜0.05）。结论 维生素D缺乏与空腹血糖、空腹胰岛素及胰岛素抵抗指数升高具有相关性，维生素D缺乏、高龄、肥胖是妊娠期糖尿病发生的危险因素。
Abstract:
Objective To investigate the relationship between serum vitamin D and glucose metabolism in the second trimester of pregnancy.Methods From January 1, 2016 to December 31, 2019, 5690 pregnant women with complete data at 24-28 weeks of pregnancy in our hospital were selected as subjects. According to their serum vitamin D levels, they were divided into vitamin D deficiency group (4517 cases) and normal group (1173 cases). The relationship between vitamin D deficiency and three blood glucose, fasting insulin and insulin resistance (HOMA-IR) in oral glucose tolerance test (OGTT), as well as the influencing factors of gestational diabetes were analyzed.Results In the vitamin D deficiency group, the fasting glucose level was (4.60±0.50)mmol/L, the fasting insulin level was (8.52±4.13)uU/ml, and the insulin resistance index was (1.77±1.01), which were higher than those of (4.56±0.46)mmol/L, (8.18±4.03)uU/ml and (1.68±0.96) in the normal group, respectively, and the differences were statistically significant (P<0.05). Linear regression analysis showed that vitamin D deficiency was negatively correlated with fasting blood glucose, fasting insulin and insulin resistance index(P<0.05). Logistic regression analysis showed that vitamin D deficiency, advanced age and obesity were risk factors for gestational diabetes mellitus (OR=1.184, 1.918, 2.497, P<0.05).Conclusion Vitamin D deficiency is correlated with fasting blood glucose, fasting insulin and insulin resistance index. Vitamin D deficiency, advanced age and obesity are risk factors for gestational diabetes mellitus.

参考文献/References:

[1]金丹,尹万军,姚梦楠,等.孕中期维生素D水平与脂代谢关联的研究[J].中华流行病学杂志,2017,40(7):815-820.[2]Demer LL,Hsu JJ,Tintut Y.Steroid Hormone Vitamin D:Implications for Cardiovascular Disease[J].Progress in Lipid Research,2018,122(11):1576-1585.[3]Mack LR,Tomich PG.Gestational disbetes:diagnosis,classification,and clinicalcare[J].Obstet Gynecol Clin North Am,2017,44(2):207-217.[4]Muche AA,Olayemi OO,Gete YK.Effects of gestational diabetes mellitus on risk of adverse maternal outcomes:a prospective cohort study in Northwest Ethiopia[J].BMC Pregnancy and Childbirth,2020,20(1):1-13.[5]刘天骄,梅又文,樊欣,等.妊娠期糖尿病对双胎妊娠孕妇的母儿结局及双生子12月龄生长状况影响的巢式病例对照研究[J].实用妇产科杂志,2021,37(5):358-363.[6]Lai FY,Johnson JA,Dover D,et al.Outcome of singleton and twin pregnancies complicated by pre-existing diabetes and gestational diabetes:a population-based study in lberta,Canada,2005-11[J].Journal of Diabetes,2016,8(1):45-55.[7]Sahin E,Col Madendag I,Sahin ME,et al.Effect of vitamin D deficiency on the 75 g oral glucose tolerance test screening and insulin resistance[J].Gynecological Endocrinology,2019,35(6):535-538.[8]刘婧,陈寒,钱年凤,等.孕中期维生D缺乏对口服葡萄糖耐量试验结果的影响[J].中国临床医生杂志,2020,48(11):1357-1359.[9]Khorasani ZM,Bonakdaran S,Rafieie HP.The Relationship Between Vitamin D Deficiency and Insulin Resistance in Pregnant Women with Gestational Diabetes[J].Current Diabetes Reviews,2019,15(5):414-419.[10]张翠军,时丽,盛玉璐,等.4103名妊娠中晚期孕妇血清25羟维生素D水平调查分析[J].实用临床医药杂志,2020,24(22):120-123.[11]Jones KS,Meadows SR,Schoenmakers I,et al.Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women[J].The Journal of Nutrition,2019,15(5):414-419.[12]王翠娟,佟来荣,孙立军,等.不同病程中的2型糖尿病患者血清胆红素、25(OH)D3与胰岛素抵抗的相关性分析[J].中国现代医学杂志,2020,16(30):45-49.[13]魏杰,张明,刘培培,等.妊娠期糖尿病孕妇血浆维生素D含量及糖化血红蛋白水平的临床研究[J].中国校医,2019,33(9):682-684.[14]Azzam EZ,El-Aghoury AA,Abd El-Naby EE,et al.Studying the relation between vitamin D deficiency and glycemic state among pregnant women with gestational diabetes[J].Diabetes Metabolic Syndrome,2019,13(2):1505-1509.[15]Xu C,Ma HH,Wang Y.Maternal Early Pregnancy Plasma Concentration of 25-Hydroxyvitamin D and Risk of Gestational Diabetes Mellitus[J].Calcified Tissue International,2018,102(3):280-286.[16]Hermes GDA,Reiders D,Kootte RS,et al.Individual and cohort-specific gut microbiota patterns associated with tissue-specific insulin sensitivity in overweight and obese males[J].Scientific Reports,2020,10(1):7523.[17]Saltiel AR,Olefsky JM.Inflammatory mechanisms linking obesity and metabolic disease[J].J Clin Invest,2017,127(1):1-4.[18]Esakoff TE,Guillet A,Caughey AB.Does small for gestational age worsen outcomes in geststional diabetics?[J].J Matern Fetal Neonatal Med,2017,30(8):890-893.

相似文献/References:

[1]付庆萍,黄万秀,李 毅.维生素D水平与成人哮喘及非哮喘的相关性研究[J].医学信息,2019,32(05):87.[doi:10.3969/j.issn.1006-1959.2019.05.026]
　FU Qin-ping,HUANG Wang-xiu,LI Yi.Correlation between Vitamin D Levels and Adult Asthma and Non-asthma[J].Medical Information,2019,32(07):87.[doi:10.3969/j.issn.1006-1959.2019.05.026]
[2]黄 铃,孙 冰,蔡金美,等.维生素D治疗川崎病的疗效及其对血清促炎因子的影响[J].医学信息,2019,32(18):81.[doi:10.3969/j.issn.1006-1959.2019.18.025]
　HUANG Ling,SUN Bing,CAI Jin-mei,et al.Therapeutic Effect of Vitamin D on Kawasaki Disease and Its Effect on Serum Pro-inflammatory Factors[J].Medical Information,2019,32(07):81.[doi:10.3969/j.issn.1006-1959.2019.18.025]
[3]陈玉峰,汪 虹,林晓莹,等.烧伤后糖代谢与免疫反应的关系[J].医学信息,2020,33(10):45.[doi:10.3969/j.issn.1006-1959.2020.10.013]
　CHEN Yu-feng,WANG Hong,LIN Xiao-ying,et al.Relationship Between Glucose Metabolism and Immune Response After Burn[J].Medical Information,2020,33(07):45.[doi:10.3969/j.issn.1006-1959.2020.10.013]
[4]张正超,李毓龙,贺 腊,等.2019年简阳地区儿童维生素D营养状况调查[J].医学信息,2020,33(11):131.[doi:10.3969/j.issn.1006-1959.2020.11.041]
　ZHANG Zheng-chao,LI Yu-long,HE La,et al.2019 Survey of Vitamin D Nutrition Status of Children in Jianyang District[J].Medical Information,2020,33(07):131.[doi:10.3969/j.issn.1006-1959.2020.11.041]
[5]白玉芬,徐洪涛,尹太勇,等.维生素D对系统性红斑狼疮鼠Peyer小结Tfh细胞微环境的影响[J].医学信息,2020,33(13):49.[doi:10.3969/j.issn.1006-1959.2020.13.014]
　BAI Yu-fen,XU Hong-tao,YIN Tai-yong,et al.The Effect of Vitamin D on the Microenvironment of Tfh Cells in Peyer’s Nodules of Systemic Lupus Erythematosus[J].Medical Information,2020,33(07):49.[doi:10.3969/j.issn.1006-1959.2020.13.014]
[6]郑鑫辉,崔慧丽,杨铁毅,等.粪乳铁蛋白、维生素D水平与克罗恩病患者骨质疏松的相关性[J].医学信息,2021,34(05):114.[doi:10.3969/j.issn.1006-1959.2021.05.032]
　ZHENG Xin-hui,CUI Hui-li,YANG Tie-yi,et al.Correlation Between Fecal Lactoferrin,Vitamin D Levels and Osteoporosis in Crohn’s Disease[J].Medical Information,2021,34(07):114.[doi:10.3969/j.issn.1006-1959.2021.05.032]
[7]朱 琪,龙 菲.血清维生素D水平与高龄老年人轻度认知障碍的关系[J].医学信息,2021,34(18):74.[doi:10.3969/j.issn.1006-1959.2021.18.020]
　ZHU Qi,LONG Fei.The Relationship Between Serum Vitamin D Level and Mild Cognitive Impairment in the Elderly[J].Medical Information,2021,34(07):74.[doi:10.3969/j.issn.1006-1959.2021.18.020]
[8]孙 浩,谢睿恒,岳 勇.糖代谢异常与肌骨系统肿瘤恶性程度的相关性分析[J].医学信息,2021,34(19):116.[doi:10.3969/j.issn.1006-1959.2021.19.030]
　SUN Hao,XIE Rui-heng,YUE Yong.Analysis of the Correlation Between Abnormal Glucose Metabolism andBone Soft Tissue Tumor Malignancys[J].Medical Information,2021,34(07):116.[doi:10.3969/j.issn.1006-1959.2021.19.030]
[9]哈海枫,严鹏仲.高原人群维生素D水平的影响因素分析[J].医学信息,2022,35(12):126.[doi:10.3969/j.issn.1006-1959.2022.12.030]
　HA Hai-feng,YAN Peng-zhong.Analysis on Influencing Factors of Vitamin D Level in Plateau Population[J].Medical Information,2022,35(07):126.[doi:10.3969/j.issn.1006-1959.2022.12.030]
[10]王文建,王博韬,李昊辰,等.维生素D辅助股骨近端防旋髓内钉内固定治疗老年股骨转子间骨折的远期疗效观察[J].医学信息,2022,35(14):119.[doi:10.3969/j.issn.1006-1959.2022.14.029]
　WANG Wen-jian,WANG Bo-tao,LI Hao-chen,et al.Long-term Effect of Vitamin D Assisted Proximal Femoral Nail Anti-rotation Internal Fixation in the Treatment of Elderly Patients with Intertrochanteric Fracture of Femur[J].Medical Information,2022,35(07):119.[doi:10.3969/j.issn.1006-1959.2022.14.029]

更新日期/Last Update: 1900-01-01