[1]邵景萍.米非司酮周期疗法与孕激素治疗围绝经期异常子宫出血的临床效果[J].医学信息,2022,35(08):153-155.[doi:10.3969/j.issn.1006-1959.2022.08.039]
　SHAO Jing-ping.The Clinical Effect of Mifepristone Cycle Therapy and Progesterone in the Treatment of Perimenopausal Abnormal Uterine Bleeding[J].Medical Information,2022,35(08):153-155.[doi:10.3969/j.issn.1006-1959.2022.08.039]
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米非司酮周期疗法与孕激素治疗围绝经期异常子宫出血的临床效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年08期
页码:
153-155
栏目:
药物与临床
出版日期:
2022-04-15

文章信息/Info

Title:
The Clinical Effect of Mifepristone Cycle Therapy and Progesterone in the Treatment of Perimenopausal Abnormal Uterine Bleeding
文章编号:
1006-1959（2022）08-0153-03
作者:
邵景萍
（1.天津医科大学总医院滨海医院神经内科，天津 300480；2.河北北方学院附属第二医院心内科，河北 张家口 075100）
Author(s):
SHAO Jing-ping
(Department of Gynecology,Tianjin Jizhou District People’s Hospital,Tianjin 301900,China)
关键词:
匹伐他汀; 阿托伐他汀; 缺血性卒中; 血脂; NIHSS评分
Keywords:
ifepristone cycle therapy; Progesterone; Perimenopausal period; Abnormal uterine bleeding
分类号:
R543
DOI:
10.3969/j.issn.1006-1959.2022.08.039
文献标志码:
A
摘要:
目的 比较匹伐他汀与阿托伐他汀治疗缺血性卒中患者的疗效及安全性。方法 选取2017年10月-2018年9月天津医科大学总医院滨海医院接诊的100例缺血性卒中患者为研究对象，采用随机数字表法分为对照组和观察组，各50例。对照组采用阿托伐他汀治疗，观察组采用匹伐他汀治疗，比较两组临床治疗总有效率、血脂指标、NIHSS评分、血肌酐、尿素氮、白细胞计数、血小板计数、尿蛋白阳性率。结果 观察组治疗总有效率为86.00%，高于对照组的82.00%，差异无统计学意义（P＞0.05）；两组LDL-C、TG、TC均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；两组NIHSS评分均低于治疗前，差异有统计学意义（P＜0.05），但组间比较，差异无统计学意义（P＞0.05）；观察组血肌酐、尿素氮、白细胞计数、尿蛋白阳性率均低于对照组，血小板计数高于对照组，差异有统计学意义（P＜0.05）。结论 匹伐他汀与阿托伐他汀对缺血性卒中疗效相似，但匹伐他汀降低血脂水平更显著，且可一定程度缓解药物不良反应，具有一定的临床应用优势。
Abstract:
Objective To observe the clinical effect of mifepristone cycle therapy and progesterone in the treatment of perimenopausal abnormal uterine bleeding.Methods A total of 72 patients with perimenopausal abnormal uterine bleeding treated in our hospital from June 2020 to June 2021 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 36 cases in each group. The control group was treated with progesterone, and the observation group was treated with mifepristone cycle therapy. The clinical efficacy, endometrial thickness, menstrual cycle, bleeding control time, sex hormone levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 88.89%, which was higher than 77.78% of the control group, and the difference was statistically significant (P<0.05). The endometrial thickness of the two groups was lower than that before treatment, and the observation group was lower than the control group, the difference was statistically significant (P<0.05). The bleeding control time and menstrual cycle of the observation group were shorter than those of the control group, and the difference was statistically significant (P<0.05). The levels of estradiol in the observation group were lower than those in the control group, and the levels of follicle estrogen and luteinizing hormone in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 5.56%, which was lower than 13.89% in the control group, and the difference was statistically significant (P<0.05).Conclusion The total effective rate of mifepristone cycle therapy in the treatment of perimenopausal abnormal uterine bleeding is high, which can quickly control abnormal bleeding, shorten menstrual cycle, improve sex hormone levels, have fewer adverse reactions and good safety.

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更新日期/Last Update: 1900-01-01