[1]穆妮热·麦麦提吐孙,阿卜杜凯尤木·库尔班.孟鲁司特钠联合布地奈德治疗小儿支气管哮喘的疗效及对患儿肺功能、外周血嗜酸性粒细胞的影响[J].医学信息,2023,36(21):138-141.[doi:10.3969/j.issn.1006-1959.2023.21.032]
　EosinophilsMunige·McMetitosun,Abdolkayum·Kurbane.Efficacy of Montelukast Sodium Combined with Budesonide in the Treatment of Bronchial Asthma in Children and its Effect on Lung Function and Peripheral Blood[J].Journal of Medical Information,2023,36(21):138-141.[doi:10.3969/j.issn.1006-1959.2023.21.032]
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孟鲁司特钠联合布地奈德治疗小儿支气管哮喘的疗效及对患儿肺功能、外周血嗜酸性粒细胞的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年21期
页码:
138-141
栏目:
药物与临床
出版日期:
2023-11-01

文章信息/Info

Title:
Efficacy of Montelukast Sodium Combined with Budesonide in the Treatment of Bronchial Asthma in Children and its Effect on Lung Function and Peripheral Blood
文章编号:
1006-1959（2023）21-0138-04
作者:
穆妮热·麦麦提吐孙; 阿卜杜凯尤木·库尔班
（喀什地区第一人民医院儿内二科，新疆 喀什 844000）
Author(s):
EosinophilsMunige·McMetitosun;  Abdolkayum·Kurbane
(The Second Department of Pediatric Medicine,the First People’s Hospital of Kashgar,Kashgar 844000,Xinjiang,China)
关键词:
支气管哮喘; 孟鲁司特钠; 布地奈德; 肺功能; 嗜酸性粒细胞
Keywords:
Bronchial asthma; Montelukast sodium; Budesonide; Lung function; Eosinophil
分类号:
R562.2+5
DOI:
10.3969/j.issn.1006-1959.2023.21.032
文献标志码:
A
摘要:
目的 探讨应用孟鲁司特钠联合布地奈德治疗小儿支气管哮喘（BA）的效果及对患儿肺功能、外周血嗜酸性粒细胞（EOS）水平的影响。方法 选择2022年2月-2023年2月我院收治的小儿BA患者90例，按照随机数字表法分成研究组（n=45）与对照组（n=45）。均采取吸氧、抗感染、补水补液干预，在此基础上对照组给予吸入用布地奈德混悬液治疗，研究组给予孟鲁司特钠联合布地奈德治疗。比较两组治疗效果、第1 s用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1/FVC、白三烯（白三烯B4、白三烯C4、白三烯D4）、外周血EOS水平及不良反应发生情况。结果 研究组治疗总有效率为93.33%，高于对照组的75.56%（P＜0.05）；两组治疗后FEV1、FVC、FEV1/FVC均高于治疗前，且研究组FEV1、FVC、FEV1/FVC高于对照组（P＜0.05）；两组治疗1个月后白三烯B4、白三烯C4、白三烯D4、外周血EOS均下降，且研究组各指标低于对照组（P＜0.05）；研究组不良反应发生率为13.33%，与对照组的8.89%比较，差异无统计学意义（P＞0.05）。结论 孟鲁司特钠联合布地奈德治疗小儿BA的效果良好，可以有效改善患儿的症状体征，提高患儿肺功能，降低外周血EOS水平，且不良反应发生率低，值得应用。
Abstract:
Objective To investigate the effect of montelukast sodium combined with budesonide in the treatment of bronchial asthma (BA) in children and its effect on lung function and peripheral blood eosinophil (EOS) level.Methods Ninety children with BA admitted to our hospital from February 2022 to February 2023 were selected and divided into study group (n=45) and control group (n=45) according to the random number table method. All patients were treated with oxygen inhalation and anti-infection rehydration intervention. On this basis, the control group was given budesonide suspension for inhalation, and the study group was treated with montelukast sodium combined with budesonide. The treatment effect, forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, leukotriene (leukotriene B4, leukotriene C4, leukotriene D4), peripheral blood EOS level and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 93.33%, which was higher than 75.56% in the control group (P<0.05). After treatment, FEV1, FVC and FEV1/FVC in the two groups were higher than those before treatment, and FEV1, FVC and FEV1/FVC in the study group were higher than those in the control group (P<0.05). After 1 month of treatment, leukotriene B4, leukotriene C4, leukotriene D4 and peripheral blood EOS decreased in both groups, and the indexes in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the study group was 13.33%, which was compared with 8.89% in the control group, the difference was not statistically significant (P>0.05).Conclusion Montelukast sodium combined with budesonide is effective in the treatment of BA in children, which can effectively improve the symptoms and signs of children, improve the lung function of children, reduce the level of EOS in peripheral blood, and the incidence of adverse reactions is low.

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更新日期/Last Update: 1900-01-01