[1]颜忠光,金益荣,段丽晖.URL术式治疗肾结石患者的临床疗效及对肾损伤因子、凝血功能及氧化应激产物的影响[J].医学信息,2024,37(14):111-114.[doi:10.3969/j.issn.1006-1959.2024.14.021]
　YAN Zhong-guang,JIN Yi-rong,DUAN Li-hui.Clinical Efficacy of URL in the Treatment of Patients with Renal Calculi and its Effects on Renal Injury Factors, Coagulation Function and Oxidative Stress Products[J].Journal of Medical Information,2024,37(14):111-114.[doi:10.3969/j.issn.1006-1959.2024.14.021]
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URL术式治疗肾结石患者的临床疗效及对肾损伤因子、凝血功能及氧化应激产物的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年14期
页码:
111-114
栏目:
论著
出版日期:
2024-07-15

文章信息/Info

Title:
Clinical Efficacy of URL in the Treatment of Patients with Renal Calculi and its Effects on Renal Injury Factors, Coagulation Function and Oxidative Stress Products
文章编号:
1006-1959（2024）14-0111-04
作者:
颜忠光; 金益荣; 段丽晖
（1.安福县中医院泌尿外科，江西 安福 343200；2.安福县人民医院外科，江西 安福 343200）
Author(s):
YAN Zhong-guang; JIN Yi-rong; DUAN Li-hui
(1.Department of Urology,Anfu County Hospital of Traditional Chinese Medicine,Anfu 343200,Jiangxi,China;2.Department of Surgery,Anfu County People’s Hospital,Anfu 343200,Jiangxi,China)
关键词:
URL术式; 肾结石; 肾损伤; 凝血功能; 氧化应激产物
Keywords:
URL operation; Renal calculus; Kidney injury; Coagulation function; Oxidative stress products
分类号:
R692.4
DOI:
10.3969/j.issn.1006-1959.2024.14.021
文献标志码:
A
摘要:
目的 研究URL术式治疗肾结石患者的临床疗效及对肾损伤因子、凝血功能及氧化应激产物的影响。方法 选取2022年1月-12月安福县中医院治疗85例肾结石患者为研究对象，采用随机数字表法分为对照组（n=42）和观察组（n=43），对照组采用经皮肾镜手术治疗，观察组采用经输尿管软镜手术（URL）治疗，比较两组临床疗效、肾损伤因子[肌酐（Scr）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、半胱氨酸蛋白酶抑制剂C（CysC）]、凝血功能指标[凝血反应时间（R值）、血凝块形成的时间（K值）、最大宽度值（MA值）]、氧化应激产物[超氧化物歧化酶（SOD）、丙二醛（MDA）]及并发症发生率。结果 观察组临床治疗总有效率为93.01%，与对照组的90.48%比较，差异无统计学意义（P＞0.05）；两组术后NGAL、CysC、Scr均高于术前，但观察组NGAL低于对照组，CysC高于对照组（P＜0.05），而两组术后Scr比较，差异无统计学意义（P＞0.05）；两组术后R值、K值低于术前，MA值高于术前，但观察组R值、K值高于对照组（P＜0.05），而两组术后MA值比较，差异无统计学意义（P＞0.05）；两组术后SOD低于术前，MDA高于术前，但观察组SOD高于对照组，MDA低于对照组（P＜0.05）；观察组并发症发生率与对照组比较，差异无统计学意义（P＞0.05）。结论 URL治疗肾结石可实现与经皮肾镜手术治疗相似的临床疗效，且可减小对肾功能、氧化应激及凝血功能的影响，可作为临床治疗肾结石的首选手术方法。
Abstract:
Objective To study the clinical efficacy of URL in the treatment of patients with renal calculi and its effects on renal injury factors, coagulation function and oxidative stress products.Methods A total of 85 patients with renal calculi treated in Anfu County Hospital of Traditional Chinese Medicine from January to December 2022 were selected as the research objects. They were divided into control group (n=42) and observation group (n=43) by random number table method. The control group was treated with percutaneous nephrolithotomy, and the observation group was treated with flexible ureteroscopy (URL). The clinical efficacy, renal injury factors [creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), cysteine protease inhibitor C (CysC)], coagulation function indexes [coagulation reaction time (R value), blood clot formation time (K value), maximum width value (MA value)], oxidative stress products [superoxide dismutase (SOD), malondialdehyde (MDA)] and complication rate were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.01%, which was compared with 90.48% in the control group, the difference was not statistically significant (P>0.05). NGAL, CysC and Scr in the two groups after operation were higher than those before operation, but NGAL in the observation group was lower than that in the control group, and CysC was higher than that in the control group (P<0.05), while there was no significant difference in Scr index between the two groups (P>0.05). The R value and K value of the two groups after operation were lower than those before operation, and the MA value was higher than that before operation, but the R value and K value of the observation group were higher than those of the control group (P<0.05), while there was no significant difference in MA value between the two groups (P>0.05). The SOD of the two groups after operation was lower than that before operation, and the MDA was higher than that before operation, but the SOD of the observation group was higher than that of the control group, and the MDA was lower than that of the control group (P<0.05).Conclusion URL can achieve similar clinical efficacy as percutaneous nephrolithotomy in the treatment of renal calculi, and can reduce the effects on renal function, oxidative stress and coagulation function. It can be used as the first choice for clinical treatment of renal calculi.

参考文献/References:

[1]Michael KGFT,Michael S,Abusada E,et al.Does the mineral content of tap water correlate with urinary calculus composition[J].Urolithiasis,2022,50(6):691-699.[2]韩孝洲,赵诚,刘剑,等.一期与二期行输尿管软镜钬激光碎石术治疗输尿管上段结石的疗效比较[J].重庆医学,2023,9(8):63-65,113-115.[3]Cao Y,Han X,Wang X,et al.Risk factors of urinary calculi in men with gout[J].Clin Rheumatol,2022,41(10):3143-3150.[4]李思宁,朱砂,苏劲,等.输尿管软镜碎石术与经皮肾镜取石术治疗直径2~4 cm肾结石的临床疗效对比[J].中华实验外科杂志,2023,40(4):750-754.[5]陈华威.输尿管软镜碎石术术后发热的危险因素分析[D].长春:吉林大学,2023.[6]张恒,张劲松,邢雷,等.输尿管软镜碎石术在孤立肾与非孤立肾结石中的临床分析[J].昆明医科大学学报,2021,42(2):91-95.[7]顾志文,郑彬,宋生生,等.输尿管软镜下“颗粒化”碎石取石术治疗≥2 cm上尿路结石(附 77例报告)[J].国际泌尿系统杂志,2020,40(5):888-890.[8]邓小林,宋乐明,钟久庆,等.智能监控腔内压力的输尿管硬镜吸引取石术治疗复杂输尿管结石[J].中国现代医学杂志,2018,28(4):120-123.[9]甘晶.对比经皮肾镜和经输尿管软镜治疗肾结石的临床疗效[J].吉林医学,2019,40(6):1197-1200.[10]王世伟,徐雪峰,赵学良,等.三种微创术式治疗输尿管上段复杂性结石疗效及对肾功能、术后疼痛的影响[J].西部医学,2023,35(2):238-241,246.[11]罗继毅,李成山.输尿管软镜治疗肾结石的效果及对肾损伤因子、炎症因子表达水平的影响[J].四川医学,2019,40(7):702-706.[12]Jiang K,Tang K,Xu H,et al.Retroperitoneoscopy Technique-Assisted Percutaneous Nephrolithotomy for Complexity Horseshoe Kidney with Renal Stones[J].Urologia Internationalis,2016,97(3):285-291．[13]向芹,刘跃光,李文科,等.输尿管软镜与经皮肾镜在肾结石患者中的应用及对肾功能凝血功能及氧化应激产物的影响[J].河北医学,2018,24(9):1522-1527.[14]张学齐,郭吉楠,杨江根,等.输尿管软镜联合钬激光碎石术治疗上尿路结石临床观察[J].现代中西医结合杂志,2016(4):354-356,420.[15]江锋,吴鹏飞.输尿管软镜下钬激光碎石术治疗肾结石的疗效和安全性研究[J].陕西医学杂志,2018,47(8):1000-1002.[16]徐宝海,江铎.标准与微通道经皮肾镜取石术治疗肾结石效果分析[J].陕西医学杂志,2018,47(1):29-31.[17]杨杰,尹小兵.输尿管软镜与经皮肾镜治疗肾结石的相关研究[J].中国现代医学杂志,2017,27(23):61-64.[18]吴猛,刘良兵,易东风.软性输尿管镜钬激光碎石术与经皮肾镜碎石取石术治疗直径≤2 cm肾结石5年回顾性分析[J].临床外科杂志,2017,25(6):469-471.[19]王勤军,刘同族,方少洪,等.输尿管软镜与经皮肾镜治疗直径2 cm以下肾结石的对照研究[J].海南医学,2018,29(7):1003-1005.

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更新日期/Last Update: 1900-01-01