[1]柴青辉.血液透析联合血液灌流治疗对慢性肾病患者血清钙磷、血脂和肾功能指标的影响[J].医学信息,2024,37(24):89-91,103.[doi:10.3969/j.issn.1006-1959.2024.24.024]
　CHAI Qinghui.Effects of Hemodialysis Combined with Hemoperfusion on Serum Calcium and Phosphorus, Blood Lipid and Renal Function Indexes in Patients with Chronic Kidney Disease[J].Journal of Medical Information,2024,37(24):89-91,103.[doi:10.3969/j.issn.1006-1959.2024.24.024]
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血液透析联合血液灌流治疗对慢性肾病患者血清钙磷、血脂和肾功能指标的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年24期
页码:
89-91,103
栏目:
论著
出版日期:
2024-12-15

文章信息/Info

Title:
Effects of Hemodialysis Combined with Hemoperfusion on Serum Calcium and Phosphorus, Blood Lipid and Renal Function Indexes in Patients with Chronic Kidney Disease
文章编号:
1006-1959（2024）24-0089-04
作者:
柴青辉
万年县人民医院肾内科，江西 万年 335500
Author(s):
CHAI Qinghui
Nephrology Department of Wannian County People’s Hospital,Wannian 335500,Jiangxi,China
关键词:
血液透析; 血液灌流; 慢性肾病; 肾功能; 血清钙磷含量; 血脂水平
Keywords:
Hemodialysis; Hemoperfusion; Chronic kidney disease; Renal function; Serum calcium and phosphorus content; Blood lipid levels
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2024.24.024
摘要:
目的 研究血液透析（HD）联合血液灌流（HP）治疗对慢性肾病患者血清钙磷、血脂和肾功能指标的影响。方法 以2021年7月-2023年10月万年县人民医院肾内科收治的68例慢性肾病患者为研究对象，经随机数字表法分为对照组（34例）和观察组（34例）。对照组行HP治疗，观察组则采用HD联合HP治疗，比较两组血清钙、磷水平、炎性指标[C-反应蛋白(CRP)、白介素（IL-6）]、血脂水平[甘油三酯（TG）、总胆固醇(TC)]、肾功能指标[血清肌酐（Scr）、血清尿素氮（BUN）]。结果 与治疗前比较，两组治疗后血清钙含量及Scr、BUN水平更高，磷含量及CRP、IL-6、TG、TC水平更低，且与对照组比较，观察组血清钙含量更高、磷含量及CRP、IL-6、TG、TC、Scr、BUN更低（P＜0.05）。结论 HD联合HP可纠正慢性肾病患者的钙磷代谢平衡，下调其炎性指标及血脂水平，缓解肾功能损伤。
Abstract:
Objective To study the effect of hemodialysis (HD) combined with hemoperfusion (HP) on serum calcium, phosphorus, blood lipid and renal function in patients with chronic kidney disease.Methods Using the random number table method, totally 68 patients with chronic kidney disease admitted to the Department of Nephrology, Wannian County People’s Hospital from July 2021 to October 2023 were divided into control group (34 patient) and observation group (34 patient). In the control group, patients were treated with HP, while in the observation group, patient were treated with HD combined with HP. The serum calcium and phosphorus levels, inflammatory indexes [C-reactive protein (CRP), interleukin (IL-6)], blood lipid levels [triglyceride (TG), total cholesterol (TC)], renal function indexes [serum creatinine (Scr), serum urea nitrogen (BUN)] were compared between the two groups.Results Compared with before treatment, the serum calcium content, Scr and BUN levels were higher, and the phosphorus content, CRP, IL-6, TG and TC levels were lower in the two groups after treatment, while compared with the control group, the serum calcium content was higher, and the phosphorus content, CRP, IL-6, TG, TC, Scr and BUN were lower in the observation group (P<0.05).Conclusion HD combined with HP can correct the balance of calcium and phosphorus metabolism in patients with chronic kidney disease, down-regulate their inflammatory indicators and blood lipid levels, and alleviate renal function damage.

参考文献/References:

[1]杨清柏,陈志忠,陈红.血液灌流联合维持性血液透析在降低慢性肾衰竭并发症中的应用[J].山西医药杂志,2020,49(17):2272-2275.[2]郑丽华.高通量血液透析对尿毒症患者的钙磷代谢、微炎症状态及尿素透析充分性的影响[J].医学信息,2023,36(11):99-101,113.[3]孙丽悦,王兰香,张颖,等.血液灌流联合序贯透析治疗终末期肾脏疾病MDA、KT/V及Hb水平变化分析 [J].分子诊断与治疗杂志,2023,15(9):1496-1500.[4]周灵杰,李媛媛,苑金花,等.血液透析联合血液灌流对维持性血液透析患者的临床疗效观察[J].新疆医科大学学报,2022,45(4):401-405.[5]李华,雷鑫,王瑛.血液透析联合血液灌流治疗终末期糖尿病肾病的疗效及对患者糖脂代谢、凝血功能指标的影响[J].海南医学,2022,33(24):3144-3147.[6]赵冬梅,夏志红,苏惠娟.血液透析联合血液灌流在维持性血液透析合并脂质代谢异常患者中的应用 [J].海南医学,2022,33(13):1646-1649.[7]白石,毕丽丽.血液透析联合血液灌流治疗对慢性肾衰竭患者临床疗效、肾功能及炎性因子的影响研究[J].贵州医药,2022,46(5):701-702.[8]陈晖,曹昉,袁飞远.肾复康胶囊结合缬沙坦胶囊对慢性肾小球肾炎疗效、肾功能、血清炎症因子影响研究[J].中华中医药学刊,2021,39(9):177-180.[9]覃源,曾凝,李莉,等.血液透析联合血液灌流治疗尿毒症对患者残余肾功能及血清肌酐、β2-MG水平的影响[J].临床和实验医学杂志,2022,21(10):1064-1067.[10]刘博,王亚丽,柳冰.两种血液净化方式对慢性肾功能衰竭尿毒症患者肾功能指标及相关并发症的影响[J].临床和实验医学杂志,2020,19(21):2319-2322.[11]王晓英,杨智勇,李晶,等.血液透析联合血液灌流及依达拉奉对尿毒症RLS患者外周血清中毒素水平、临床症状及睡眠质量的影响[J].现代生物医学进展,2022,22(4):770-774.[12]Zhao D,Wang Y,Wang Y,et al.Randomized Control Study on Hemoperfusion Combined with Hemodialysis versus Standard Hemodialysis: Effects on Middle-Molecular-Weight Tox ins and Uremic Pruritus[J].Blood Purif,2022,1-11.[13]庄凌,周惠,陈连华,等.血液灌流联合血液透析与血液透析滤过在预防维持性血液透析心脏瓣膜钙化中的应用[J].临床肾脏病杂志,2020,20(1):69-72.[14]高乐,韩亚男,张振宇.血液透析联合血液灌流治疗对慢性肾衰竭微炎症状态、认知功能及肾功能的影响[J].解放军医药杂志,2021,33(8):83-86.[15]刘智美,王娅敏,李文巧,等.血液透析联合HP治疗对慢性肾衰竭患者的临床疗效及对炎性因子和钙磷代谢的影响[J].西部医学,2021,33(9):1364-1368.[16]黄程,黄卫民,邵云侠,等.血液灌流联合血液透析疗法对肾衰竭伴钙磷代谢异常患者血清PTH水平变化及临床效果研究[J].中国中西医结合肾病杂志,2021,22(3):245-247.[17]宋菊香,夏薇青,马辉,等.不同血液净化方式对维持性血液透析患者矿物质及骨代谢状况的影响[J].河北医学,2021,27(1):105-109.[18]仲雅,李亚娟,齐小玲,等.血液透析联合血液灌流对慢性肾衰竭患者临床疗效、肾功能及血清炎性因子的影响[J].解放军医药杂志,2020,32(12):77-80.[19]李素娜,王晓林,付景斐,等.血液灌流联合透析对慢性肾病患者残余肾功能及血清VEGF、ET-1的影响[J].分子诊断与治疗杂志,2022,14(5):781-784.[20]陈海玲,刘敏,余霞.血液透析协同血液灌流对维持性血透患者的疗效指标及安全性分析[J].中国病案,2020,21(9):109-112.[21]李京,王怡,李霞.血液透析联合血液灌流治疗对慢性肾病患者钙磷和脂质代谢的影响[J].重庆医学,2020,49(09):1409-1412.[22]王奕,王朝霞,马世兴,等.血液灌流串联血液透析对尿毒症患者微炎状态和心脑血管事件的影响分析[J].中华保健医学杂志,2020,22(2):173-175.[23]焦丽娟,王婷,李媛媛,等.血液透析联合血液灌流治疗慢性肾脏病终末期患者及对微炎症反应肾功能的影响[J].河北医学,2023,29(11):1832-1837.

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更新日期/Last Update: 1900-01-01