[1]李钦涛.不同剂量肝素在血液灌流治疗农药中毒中的应用[J].医学信息,2019,(20):110-111.[doi:10.3969/j.issn.1006-1959.2019.19.032]
 LI Qin-tao.Application of Different Doses of Heparin in the Treatment of Pesticide Poisoning by Blood Perfusion[J].Medical Information,2019,(20):110-111.[doi:10.3969/j.issn.1006-1959.2019.19.032]
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不同剂量肝素在血液灌流治疗农药中毒中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2019年20期
页码:
110-111
栏目:
临床研究
出版日期:
2019-10-15

文章信息/Info

Title:
Application of Different Doses of Heparin in the Treatment of Pesticide Poisoning by Blood Perfusion
文章编号:
1006-1959(2019)19-0110-02
作者:
李钦涛
(东阿县人民医院重症医学科,山东 东阿 252200)
Author(s):
LI Qin-tao
(Department of ICU,Dong'e County People's Hospital,Dong'e 252200,Shandong,China)
关键词:
血液灌流中毒肝素
Keywords:
Blood perfusionPoisoningHeparin
分类号:
R472
DOI:
10.3969/j.issn.1006-1959.2019.19.032
文献标志码:
A
摘要:
目的 分析血液灌流治疗农药中毒中肝素的用量。方法 选取2017年1月~2018年12月我院重症医学科收治的农药中毒患者116例,按照肝素使用剂量的不同分成两组,其中采用首剂量0.5 mg/kg者63例设为A组,采用首剂量8 mg/kg者53例设为B组,比较两组不同时间段血小板计数、APTT指标以及出血发生率。结果 两组治疗前及治疗后24、48、72 h血小板计数指标比较,差异均无统计学意义(P>0.05);治疗后4 h,B组血小板计数为(150.92±23.83)×109/L,低于A组的(178.73±39.18)×109/L,差异有统计学意义(P<0.05);两组治疗前后48、72 h APTT比较,差异均无统计学意义(P>0.05);治疗后A组4、24 h APTT较B组延长,差异有统计学意义(P<0.05);B组出血发生率为5.67%,低于A组的22.22%,差异有统计学意义(P<0.05)。结论 农药中毒患者血液灌流治疗中肝素首剂量采用8 mg/kg,效果较好,对血液抗凝效果较好,出血率低。
Abstract:
Objective To analyze the amount of heparin in the treatment of pesticide poisoning by blood perfusion.Methods A total of 116 patients with pesticide poisoning admitted to our Department of Critical Care Medicine from January 2017 to December 2018 were enrolled. The patients were divided into two groups according to the dose of heparin. There were 63 patients in group A and 53 patients in group B. The first dose was 0.5 mg. The patients with /kg were set to group A, and the first dose of 8 mg/kg was used as group B. The platelet count, APTT index and bleeding rate were compared between the two groups. Results There were no significant differences in platelet counts between the two groups before treatment and at 24, 48, and 72 h after treatment (P>0.05). At 4 h after treatment, the platelet count of group B was (150.92±23.83)×109/L,below the group A (178.73 ± 39.18) × 109/L,the difference was statistically significant (P<0.05). There was no significant difference in APTT between the two groups at 48 and 72 h before and after treatment (P>0.05). After treatment, the APTT at 4 and 24 h in group A was longer than that in group B,the difference was statistically significant (P<0.05). The incidence of bleeding in group B was 5.67%, which was lower than 22.22% in group A,the difference was statistically significant (P<0.05).Conclusion In the treatment of patients with pesticide poisoning, the first dose of heparin in the treatment of blood perfusion is 8 mg/kg, the effect is better, the anticoagulation effect on blood is better, and the bleeding rate is lower.

参考文献/References:

[1]赵国红.对急性重度有机磷农药中毒患者进行血液灌流治疗的效果分析[J].当代医药论丛,2016,14(10):163-164. [2]孙艳红,王克民.依诺肝素钠抗凝在急性中毒血液灌流中的临床分析[J].系统医学,2018,3(21):53-55. [3]李红英,熊伟.维持性血液透析患者血液灌流凝血原因分析及护理进展[J].中国现代药物应用,2018,12(18):215-216. [4]杨素云,刘晓彬.高浓度肝素盐水封管对急性重度中毒患者血液灌流期间导管堵塞及出血风险的影响[J].国际检验医学杂志,2018,39(15):1824-1826,1831. [5]张海钢,吴京兰,黄镭,等.局部枸橼酸抗凝在重症中毒患者血液灌流治疗中的应用研究[J].中国血液净化,2018,17(4):217-221.

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更新日期/Last Update: 2019-10-15