[1]刘腾雁,戴丽芬,彭娅萍,等.缺氧诱导因子-1α对OSAHS患者糖代谢的影响研究[J].医学信息,2023,36(01):189-192.[doi:10.3969/j.issn.1006-1959.2023.01.042]
 LIU Teng-yan,DAI Li-fen,PENG Ya-ping,et al.Effect of Hypoxia-inducible Factor-1α on Glucose Metabolism in Patients with OSAHS[J].Journal of Medical Information,2023,36(01):189-192.[doi:10.3969/j.issn.1006-1959.2023.01.042]
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缺氧诱导因子-1α对OSAHS患者糖代谢的影响研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年01期
页码:
189-192
栏目:
综述
出版日期:
2023-01-01

文章信息/Info

Title:
Effect of Hypoxia-inducible Factor-1α on Glucose Metabolism in Patients with OSAHS
文章编号:
1006-1959(2023)01-0189-04
作者:
刘腾雁戴丽芬彭娅萍
(昆明医科大学第二附属医院内分泌科,云南 昆明 650033)
Author(s):
LIU Teng-yanDAI Li-fenPENG Ya-pinget al.
(Department of Endocrinology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650033,Yunnan,China)
关键词:
阻塞性睡眠呼吸暂停低通气综合征2型糖尿病胰岛素抵抗缺氧诱导因子-1α
Keywords:
Obstructive sleep apnea hypopnea syndromeType 2 diabetes mellitusInsulin resistanceHypoxia inducible factor-1α
分类号:
R766
DOI:
10.3969/j.issn.1006-1959.2023.01.042
文献标志码:
A
摘要:
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)已被证实是2型糖尿病发生、发展和胰岛素抵抗的独立危险因素,但其具体的机理尚不明确。近年来已有研究表明,OSAHS在夜间反复间歇性缺氧状态下,可激活缺氧诱导因子-1α及其信号转导途径,而缺氧诱导因子-1α可参与调节机体代谢过程,并介导胰岛素抵抗和糖尿病的发生。因此,OSAHS患者发生糖代谢异常可能与缺氧诱导因子-1α的激活有关。除了对糖代谢的影响外,缺氧诱导因子-1α与糖尿病相关的慢性并发症的发展也有一定的关系。本文就缺氧诱导因子-1α对OSAHS患者糖代谢及相关慢性并发症的影响研究进展作一综述。
Abstract:
Obstructive sleep apnea hypopnea syndrome (OSAHS) has been identified as an independent risk factor for the onset and progression of type 2 diabetes mellitus and insulin resistance. However, the specific mechanism is still unclear. In recent years, studies have shown that the process of repeated intermittent hypoxia in OSAHS at night can activate hypoxia inducible factor-1αand its signaling pathway. HIF-1α is involved in regulating metabolic processes and mediating the development of IR and diabetes mellitus. Therefore, abnormal glucose metabolism in OSAHS patients may be related to the activation of hypoxia-inducible factor-1α. In addition to its effects on glucose metabolism, hypoxia-inducible factor-1α is also implicated in the development of diabetes-related chronic complications. This article reviews the research progress on the effects of hypoxia-inducible factor-1α on glucose metabolism and related chronic complications in patients with OSAHS.

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更新日期/Last Update: 1900-01-01