[1]李 莎,姜 崴.2型糖尿病视网膜病变患者血清ANGPTL8的水平及临床意义[J].医学信息,2024,37(07):93-97.[doi:10.3969/j.issn.1006-1959.2024.07.017]
　LI Sha,JIANG Wei.The Level and Clinical Significance of Serum ANGPTL8 in Patients with Type 2 Diabetic Retinopathy[J].Journal of Medical Information,2024,37(07):93-97.[doi:10.3969/j.issn.1006-1959.2024.07.017]
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2型糖尿病视网膜病变患者血清ANGPTL8的水平及临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年07期
页码:
93-97
栏目:
论著
出版日期:
2024-04-01

文章信息/Info

Title:
The Level and Clinical Significance of Serum ANGPTL8 in Patients with Type 2 Diabetic Retinopathy
文章编号:
1006-1959（2024）07-0093-05
作者:
李 莎; 姜 崴
（1.长江航运总医院老年病科，湖北 武汉 430000；2.哈尔滨医科大学附属第一医院内分泌科，黑龙江 哈尔滨 150007）
Author(s):
LI Sha; JIANG Wei
(1.Department of Geriatrics,General Hospital of the Yangtze River Shipping,Wuhan 430000,Hubei,China;2.Department of Endocrinology,the First Affiliated Hospital of Harbin Medical University,Harbin 150007,Heilongjiang,China)
关键词:
ANGPTL8; 2型糖尿病; 糖尿病视网膜病变; 甘油三酯
Keywords:
ANGPTL8; Type 2 diabetes mellitus; Diabetic retinopathy; Triglyceride
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2024.07.017
文献标志码:
A
摘要:
目的 通过定量检测血管生成素样蛋白8（ANGPTL8）的水平，探讨其与2型糖尿病视网膜病变严重程度的相关性。方法 选取2018年10月-2019年1月哈尔滨医科大学附属第一医院内分泌科收治的60例2型糖尿病患者，根据是否合并糖尿病视网膜病变及其分期分为单纯糖尿病组（DM组）、非增殖期糖尿病视网膜病变组（NPDR组）、增殖期糖尿病视网膜病变组（PDR组），每组20例，同时选取同一时间的20例正常体检者设为对照组（CG组）；收集入组患者的基本资料，测定糖化血红蛋白（HbA1c）、空腹C肽、空腹静脉葡萄糖（FBG）、总胆固醇（TC）、甘油三酯（TG）等生化指标；应用ELISA测定血清ANGPTL8水平。结果 四组收缩压、舒张压、BMI、C肽、TC比较，差异无统计学意义（P＞0.05）；糖尿病病程在DM组、NPDR组、PDR组三组间逐渐升高，PDR组高于DM组、NPDR组；DM组、NPDR组、PDR组HbA1c及FBG高于CG组；TG水平在CG组、DM组、NPDR组、PDR组四组间逐渐增高，PDR组、NPDR组、DM组均高于CG组，差异有统计学意义（P＜0.05）；血清ANGPTL8在CG组、DM组、NPDR组、PDR组四组间浓度逐渐增高，PDR组高于其他三组，差异有统计学意义（P＜0.05），且血清ANGPTL8的升高与TG相关（P＜0.05）。结论 ANGPTL8与糖尿病视网膜病变的严重程度具有一定的相关性，它可能在糖代谢异常的基础上通过影响TG代谢参与PDR的发生发展。
Abstract:
Objective To investigate the correlation between serum angiopoietin-like protein 8 (ANGPTL8) levels and the severity of type 2 diabetic retinopathy by quantifying its level.Methods Sixty patients with type 2 diabetes mellitus who were admitted to the Department of Endocrinology of the First Hospital of Harbin Medical University from October 2018 to January 2019 were selected. According to the presence or absence of diabetic retinopathy and its stage, they were divided into simple diabetes group (DM group), non-proliferative diabetic retinopathy group (NPDR group), and proliferative diabetic retinopathy group (PDR group), with 20 patients in each group. At the same time, 20 normal subjects at the same time were selected as the control group (CG group). The basic data of the enrolled patients were collected, and biochemical indicators such as glycated hemoglobin (HbA1c), fasting C-peptide, fasting venous glucose (FBG), total cholesterol (TC), and triglyceride (TG) were measured. Serum ANGPTL8 levels were measured by ELISA.Results There was no significant difference in systolic blood pressure, diastolic blood pressure, BMI, C-peptide and TC among the four groups (P>0.05). The course of diabetes increased gradually among DM group, NPDR group and PDR group, and that in PDR group was higher than that in DM group and NPDR group; HbA1c and FBG in DM group, NPDR group and PDR group were higher than those in CG group; the level of TG increased gradually among CG group, DM group, NPDR group and PDR group, and the level of TG in PDR group, NPDR group and DM group was higher than that in CG group (P<0.05). The concentration of serum ANGPTL8 in CG group, DM group, NPDR group and PDR group increased gradually, and that in the PDR group was higher than the other three groups, the difference was statistically significant (P<0.05), and the increase of serum ANGPTL8 was related to TG (P<0.05).Conclusion ANGPTL8 has a certain correlation with the severity of diabetic retinopathy. It may be involved in the occurrence and development of PDR by affecting TG metabolism on the basis of abnormal glucose metabolism.

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更新日期/Last Update: 1900-01-01