[1]郭云飞,王亚柱,刘 超,等.TyG指数及LDL-C/HDL-C比率与2型糖尿病合并冠心病的相关性研究[J].医学信息,2022,35(06):93-96,100.[doi:10.3969/j.issn.1006-1959.2022.06.023]
　GUO Yun-fei,WANG Ya-zhu,LIU Chao,et al.The Correlation Between TyG Index and LDL-C/HDL-C Ratio and Coronary Heart Disease in Type 2 Diabetes Mellitus[J].Medical Information,2022,35(06):93-96,100.[doi:10.3969/j.issn.1006-1959.2022.06.023]
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TyG指数及LDL-C/HDL-C比率与2型糖尿病合并冠心病的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年06期
页码:
93-96,100
栏目:
论著
出版日期:
2022-03-15

文章信息/Info

Title:
The Correlation Between TyG Index and LDL-C/HDL-C Ratio and Coronary Heart Disease in Type 2 Diabetes Mellitus
文章编号:
1006-1959（2022）06-0093-05
作者:
郭云飞; 王亚柱; 刘 超; 等
（承德医学院附属医院麻醉科1，心血管内科2，河北 承德 067000）
Author(s):
GUO Yun-fei; WANG Ya-zhu; LIU Chao; et al.
(Department of Anesthesiology1,Department of Cardiovascular Medicine2,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)
关键词:
冠心病; 2型糖尿病; 三酰甘油葡萄糖乘积指数; 低密度脂蛋白胆固醇
Keywords:
Coronary heart disease; Type 2 diabetes mellitus; Triacylglycerol glucose product index; Low density lipoprotein cholesterol
分类号:
R541.4；R587.1
DOI:
10.3969/j.issn.1006-1959.2022.06.023
文献标志码:
A
摘要:
目的 探讨三酰甘油葡萄糖乘积指数（TyG指数）及LDL-C/HDL-C比率与2型糖尿病（T2DM）合并冠心病（CHD）的相关性。方法 选择2016年12月-2018年7月就诊于我院疑诊为CHD并行冠状动脉造影检查的T2DM患者387例，依据冠状动脉造影结果将确诊为CHD的患者设为研究组（283例），无CHD的患者设为对照组（104例），记录患者的临床资料、生化检测指标及冠状动脉影像学资料，并计算TyG指数、LDL-C/HDL-C比率及Gensini评分；比较两组临床资料、TyG指数、LDL-C/HDL-C比率，采用受试者工作特征曲线（ROC）评估TyG指数、LDL-C/HDL-C比率对T2DM合并CHD的诊断价值，并确定最佳截断值；Logistic回归分析T2DM合并CHD的危险因素；Spearman相关性分析TyG指数、LDL-C/HDL-C比率与Gensini评分的相关性。结果 研究组TyG指数、LDL-C/HDL-C比率均高于对照组（P＜0.05）；ROC曲线分析显示，TyG指数、LDL-C/HDL-C比率诊断T2DM合并CHD的曲线下面积（AUC）分别为0.646和0.651，当TyG指数、LDL-C/HDL-C比率分别取截断值7.170、2.080时，诊断T2DM合并CHD的效能最高，诊断的敏感度和特异度分别为44.50%、84.60%和55.20%、71.40%；Logistic回归分析显示，TyG指数≥7.170、LDL-C/HDL-C比率≥2.080是T2DM合并CHD的独立危险因素（P＜0.05）；Spearman相关性分析显示，TyG指数、LDL-C/HDL-C比率与Gensini评分呈正相关（r=0.114、0.152，P＜0.05）。结论 TyG指数、LDL-C/HDL-C比率对诊断T2DM合并CHD具有提示意义，是T2DM合并CHD的独立危险因素，与T2DM患者的冠脉病变程度呈正相关。
Abstract:
Objective To investigate the correlation of triglyceride glucose product index (TyG index) and LDL-C/HDL-C ratio with type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD).Methods A total of 387 patients with T2DM who were suspected to be CHD and underwent coronary angiography in our hospital from December 2016 to July 2018 were selected. According to the results of coronary angiography, the patients diagnosed as CHD were set as the study group (283 cases), and the patients without CHD were set as the control group (104 cases). The clinical data, biochemical detection indexes and coronary artery imaging data of all patients were recorded, and the TyG index, LDL-C/HDL-C ratio and Gensini score were calculated. The clinical data, TyG index and LDL-C/HDL-C ratio were compared between the two groups. The receiver operating characteristic curve (ROC) was used to evaluate the diagnostic value of TyG index and LDL-C/HDL-C ratio for T2DM with CHD, and the optimal cutoff value was determined. Logistic regression analysis of T2DM with CHD risk factors; Spearman correlation analysis of TyG index, LDL-C/HDL-C ratio and Gensini score.Results The TyG index and LDL-C/HDL-C ratio in the study group were higher than those in the control group (P<0.05). ROC curve analysis showed that the area under the curve (AUC) of TyG index and LDL-C/HDL-C ratio in the diagnosis of T2DM combined with CHD were 0.646 and 0.651, respectively. When the cut-off values of TyG index and LDL-C/HDL-C ratio were 7.170 and 2.080, respectively, the diagnostic efficacy of T2DM combined with CHD was the highest, and the diagnostic sensitivity and specificity were 44.50%, 84.60% and 55.20%, 71.40%, respectively. Logistic regression analysis showed that TyG index≥7.170 and LDL-C/HDL-C ratio≥2.080 were independent risk factors for T2DM combined with CHD (P<0.05). Spearman correlation analysis showed that TyG index and LDL-C/HDL-C ratio were positively correlated with Gensini score (r=0.114, 0.152, P<0.05).Conclusion TyG index and LDL-C / HDL-C ratio are of significance for the diagnosis of T2DM complicated with CHD, which are independent risk factors for T2DM complicated with CHD and are positively correlated with the severity of coronary artery lesions in T2DM patients.

参考文献/References:

[1]Wang L,Gao P,Zhang M,et al.Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013[J].JAMA,2017,317(24):2515-2523.[2]Makrilakis K,Liatis S.Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros.[J].Journal of Diabetes Research,2017(2017):8927473.[3]Jegatheesan D,Cho Y,Johnson DW.Clinical Studies of Interventions to Mitigate Cardiovascular Risk in Peritoneal Dialysis Patients[J].Semin Nephrol,2018,38(3):277-290.[4]Wang C,Li F,Guo J,et al.Insulin resistance,blood glucose and inflammatory cytokine levels are risk factors for cardiovascular events in diabetic patients complicated with coronary heart disease[J].Exp Ther Med,2018,15(2):1515-1519.[5]Alizargar J,Bai CH,Hsieh NC,et al.Use of the triglyceride-glucose index (TyG) in cardiovascular disease patients[J].Cardiovascular Diabetology,2020,19(1):8.[6]Park GM,Cho YR,Won KB,et al.Triglyceride glucose index is a useful marker for predicting subclinical coronary artery disease in the absence of traditional risk factors[J].Lipids in Health and Disease,2020,19(1):7.[7]贾珏,俞淑琴,叶菁菁,等.新诊断2型糖尿病合并代谢综合征患者血清LDL-C/HDL-C比值的临床研究[J].第二军医大学学报,2014,35(12):1396-1400.[8]李明春,初少莉,左君丽,等.LDL-C/HDL-C与冠状动脉病变程度的相关性研究[J].第二军医大学学报,2014,35(3):270-273.[9]中华医学会糖尿病学分会．中国2型糖尿病防治指南(2017年版) [J].中华糖尿病杂志,2018,10(1):4-67.[10]中国高血压防治指南修订委员会,高血压联盟(中国),中华医学会心血管病学分会中国医师协会高血压专业委员会,等.中国高血压防治指南( 2018年修订版)[J].中国心血管杂志,2019,24(1):24-56.[11]中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南（2016年修订版）[J].中国循环杂志,2016,31(10):937-950.[12]颜红兵.临床冠心病诊断与治疗指南[M].北京:人民卫生出版社,2010:5-26.[13]Park K,Ahn CW,Lee SB,et al.Elevated TyG Index Predicts Progression of Coronary Artery Calcification.[J].Diabetes Care,2019,42(8):1569-1573.[14]Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J].Am J Cardiol,1983,51(3):606.[15]Lee EY,Yang HK,Lee J,et al.Triglyceride glucose index,a marker of insulin resistance,is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes[J].Lipids Health Dis,2016,15(1):155.[16]Emamalipour M,Seidi K,Jahanban-Esfahlan A,et al.Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro-inflammatory cytokines.[J].J Cell Physiol,2019,234(12):21758-21769.[17]Simental-Mendía LE,Rodríguez-Morán M,Guerrero-Romero F.The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects.[J].Metab Syndr Relat Disord,2008,6(4):299-304.[18]Zhao S,Yu S,Chi C,et al.Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study[J].Cardiovasc Diabetol,2019,18(1):95.[19]Ma X,Dong L,Shao Q,et al.Triglyceride glucose index for predicting cardiovascular outcomes after percutaneous coronary intervention in patients with type 2 diabetes mellitus and acute coronary syndrome[J].Cardiovasc Diabetol,2020,19(1):31.[20]Du R,Li M,Wang X,et al.LDL-C/HDL-C ratio associated with carotid intima-media thickness and carotid plaques in male but not female patients with type 2 diabetes[J].Clin Chim Acta,2020(511):215-220.

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