[1]曲丹丹,金军英,张维伦.尿肾功检测在早期糖尿病肾病诊断中的应用分析[J].医学信息,2019,32(09):174-175.[doi:10.3969/j.issn.1006-1959.2019.09.059]
　QU Dan-dan,JIN Jun-ying,ZHANG Wei-lun.Application of Urinary Renal Function Test in the Diagnosis of Early Diabetic Nephropathy[J].Journal of Medical Information,2019,32(09):174-175.[doi:10.3969/j.issn.1006-1959.2019.09.059]
点击复制

尿肾功检测在早期糖尿病肾病诊断中的应用分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年09期
页码:
174-175
栏目:
诊疗技术
出版日期:
2019-05-01

文章信息/Info

Title:
Application of Urinary Renal Function Test in the Diagnosis of Early Diabetic Nephropathy
文章编号:
1006-1959（2019）09-0174-02
作者:
曲丹丹; 金军英; 张维伦
（黑龙江省佳木斯市中心医院检验科，黑龙江 佳木斯 154002）
Author(s):
QU Dan-dan; JIN Jun-ying; ZHANG Wei-lun
(Department of Clinical Laboratory,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
糖尿病肾病; 尿肾功检测; 肾病早期
Keywords:
Diabetic nephropathy; Urinary renal function test; Early stage of kidney disease
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2019.09.059
文献标志码:
A
摘要:
目的 分析尿肾功检测在早期糖尿病肾病（DN）诊断中的应用价值。方法 选择2017年5月~2018年5月我院收治的100例DN患者为研究对象，设为为观察组。另选取同期来我院行健康体检者的100名健康者设为对照组，比较两组尿肾功检各项指标，包括mALB、UCr、N-AG、β2-MG以及mALB/UCr比值。结果 观察组受试者的mALB、UCr、N-AG、β2-MG以及mALB/UCr比值均高于对照组，差异有统计学意义（P＜0.05）；尿肾功检测诊断早期糖尿病肾病的阴性预测值、阳性预测值、准确度、特异度以及灵敏度分别为94.81%、87.21%，90.13%，81.94%以及96.54%。结论 尿肾功检测法，用于早期糖尿病肾病诊断，其准确性及特异性均较高。
Abstract:
Objective To analyze the value of urinary renal function test in the diagnosis of early diabetic nephropathy (DN). Methods 100 patients with DN admitted to our hospital from May 2017 to May 2018 were selected as the study group. In addition, 100 cases of healthy physical examinations in our hospital were selected as the control group, and the indexes of urinary and renal biopsy were compared between the two groups, including the ratios of mALB, UCr, N-AG, β2-MG and mAb/UCr. Results The ratios of mAb, UCr, N-AG, β2-MG and mAb/UCr in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). The urine function test was used to diagnose the early diabetic nephropathy. The predicted value, positive predictive value, accuracy, specificity and sensitivity were 94.81%,87.21%,90.13%,81.94% and 96.54%, respectively. Conclusion Urine and renal function test is used for the diagnosis of early diabetic nephropathy, and its accuracy and specificity are high.

参考文献/References:

[1]丛玉玺,张艳宁,刘瑀晗,等.前列地尔对老年早期糖尿病肾病患者炎性因子、肾功能及血管内皮功能的影响研究[J].实用老年医学,2016(5):409-411.
[2]李志恒.分析多项指标表达水平在糖尿病肾病早期诊断中的意义[J].检验医学与临床,2016,13(8):@121-122.
[3]林敏,朱柳君,莫春香,等.单光子发射计算机断层成像技术肾功能显像在早期糖尿病肾病诊断中的应用[J].广西医学,2017(12):1855-1857.
[4]詹颉,张华,闫福堂,等.血清NGAL与Cr,BUN,RBP,Cys-C联合检测在糖尿病肾病早期诊断中的应用[J].现代检验医学杂志,2016,31(4):100-103.
[5]Qiang W,Branch D,Hospital CC.Detection of serum Cys C and Hcy as well as urine mindin and NAG contents in patients with diabetic nephropathy and value for early diagnosis of disease[J]. Journal of Hainan Medical University,2016,22(10):48-51.
[6]Yang XL,Yu HJ,Zhu HY,et al.Potential Value of Datura stramonium Agglutinin-recognized Glycopatterns in Urinary Protein on Differential Diagnosis of,Diabetic Nephropathy and Nondiabetic Renal Disease[J].Chin Med J,2018(2):180-187.
[7]Zhang GZ,Zhi-Yuan LU,Ren Z,et al.Effect of sequential therapy of prostaglandins on renal function indexes in blood and urine specimens of patients with diabetic nephropathy[J].Journal of Hainan Medical University,2016,22(18):121-122.
[8]曾虹.联合检测胱抑素C、尿微量白蛋白/肌酐比值、视黄醇结合蛋白在糖尿病早期肾损伤中的临床应用[J].中国实验诊断学,2016,20(7):125-126.

相似文献/References:

[1]陈淑雯.肾衰宁联合科素亚治疗早期糖尿病肾病的临床观察[J].医学信息,2018,31(05):20.[doi:10.3969/j.issn.1006-1959.2018.05.007]
　CHEN Shu-wen.Clinical Observation on Early Diabetic Nephropathy Treated by Shenshuaining Combined with Kosu[J].Journal of Medical Information,2018,31(09):20.[doi:10.3969/j.issn.1006-1959.2018.05.007]
[2]何丽杰.中西医治疗糖尿病肾病的临床效果分析[J].医学信息,2018,31(10):149.[doi:10.3969/j.issn.1006-1959.2018.10.051]
　HE Li-jie.Clinical Effect Analysis of Diabetic Nephropathy Treated by Chinese and Western Medicine[J].Journal of Medical Information,2018,31(09):149.[doi:10.3969/j.issn.1006-1959.2018.10.051]
[3]贺 伟,高 峰.24 h尿微量白蛋白、血清胱抑素C水平与血清肌酐、尿素水平在2型糖尿病肾病早期诊断的意义[J].医学信息,2018,31(11):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
　HE Wei,GAO Feng.The Significance of 24 h Urinary Microalbumin,Serum Cystatin C and Serum Creatinine and Urea Levels in the Early Diagnosis of Type 2 Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):151.[doi:10.3969/j.issn.1006-1959.2018.11.049]
[4]黄秋菊.胱抑素C及脂蛋白α在早期糖尿病肾病诊断中的价值研究[J].医学信息,2018,31(14):57.[doi:10.3969/j.issn.1006-1959.2018.14.018]
　HUANG Qiu-ju.The Value of Cystatin C and Lipoprotein α in the Diagnosis of Early Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):57.[doi:10.3969/j.issn.1006-1959.2018.14.018]
[5]陆新虹,温玉洁,胡 欣,等.α-硫辛酸对2型糖尿病肾病患者 血清内脂素的影响研究[J].医学信息,2018,31(14):60.[doi:10.3969/j.issn.1006-1959.2018.14.019]
　LU Xin-hong,WEN Yu-jie,HU Xin,et al.Effect of α-lipoic Acid on Serum Visfatin in Patients with Type 2 Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):60.[doi:10.3969/j.issn.1006-1959.2018.14.019]
[6]肖学秀.益气活血汤联合西药治疗早期糖尿病肾病的临床观察[J].医学信息,2019,32(02):166.[doi:10.3969/j.issn.1006-1959.2019.02.051]
　XIAO Xue-xiu.Clinical Observation of Yiqi Huoxue Decoction Combined with Western Medicine in Treating Earlyn Diabetic Nephropathy[J].Journal of Medical Information,2019,32(09):166.[doi:10.3969/j.issn.1006-1959.2019.02.051]
[7]郑小鹏,辛 华.糖尿病肾病研究进展[J].医学信息,2018,31(16):26.[doi:10.3969/j.issn.1006-1959.2018.16.008]
　ZHENG Xiao-peng,XIN Hua.Progress in the Study of Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):26.[doi:10.3969/j.issn.1006-1959.2018.16.008]
[8]李志俊,王 利,王 浩.姜黄素改善糖尿病肾病的作用机制研究[J].医学信息,2018,31(24):35.[doi:10.3969/j.issn.1006-1959.2018.24.010]
　LI Zhi-jun,WANG Li,WANG Hao.Study on the Mechanism of Curcumin in Improving Diabetic Nephropathy[J].Journal of Medical Information,2018,31(09):35.[doi:10.3969/j.issn.1006-1959.2018.24.010]
[9]张国艳,张佳田,隋洪玉.糖尿病肾病大鼠动物模型建立及INF-α干预机制研究[J].医学信息,2019,32(05):101.[doi:10.3969/j.issn.1006-1959.2019.05.030]
　ZHANG Guo-yan,ZHANG Jia-tian,SUI Hong-yu.Establishment of Animal Model of Diabetic Nephropathy Rats and Study of INF-α Intervention Mechanism[J].Journal of Medical Information,2019,32(09):101.[doi:10.3969/j.issn.1006-1959.2019.05.030]
[10]吴怡琪,卢 文.皮肤AGEs荧光检测对糖尿病肾病的临床意义[J].医学信息,2019,32(06):101.[doi:10.3969/j.issn.1006-1959.2019.06.031]
　WU Yi-qi,LU Wen.Clinical Significance of Skin AGEs Fluorescence Detection in Diabetic Kidney Disease[J].Journal of Medical Information,2019,32(09):101.[doi:10.3969/j.issn.1006-1959.2019.06.031]

更新日期/Last Update: 2019-05-01