[1]匡 鑫,吴淑琼.2型糖尿病患者周围血管病变相关危险因素分析及踝肱指数的临床应用价值[J].医学信息,2022,35(05):127-130.[doi:10.3969/j.issn.1006-1959.2022.05.033]
　KUANG Xin,WU Shu-qiong.Analysis of Risk Factors Related to Peripheral Vascular Lesions in Patients with Type 2 Diabetes Mellitus and Clinical Application Value of Ankle-brachial Index[J].Medical Information,2022,35(05):127-130.[doi:10.3969/j.issn.1006-1959.2022.05.033]
点击复制

2型糖尿病患者周围血管病变相关危险因素分析及踝肱指数的临床应用价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
127-130
栏目:
临床研究
出版日期:
2022-03-01

文章信息/Info

Title:
Analysis of Risk Factors Related to Peripheral Vascular Lesions in Patients with Type 2 Diabetes Mellitus and Clinical Application Value of Ankle-brachial Index
文章编号:
1006-1959（2022）05-0127-04
作者:
匡 鑫; 吴淑琼
（1.湖北中医药大学第一临床学院，湖北 武汉 430065；2.湖北中医药大学附属新华医院/湖北省中西医结合医院内分泌科，湖北 武汉 430015）
Author(s):
KUANG Xin; WU Shu-qiong
(1.The First Clinical College,Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China;2.Department of Endocrinology,Xinhua Hospital of Hubei University of Chinese Medicine/Hubei Provincial Hospital ofIntegrated Chinese and Western Medicine,Wuhan 430015,Hubei,China)
关键词:
2型糖尿病; 糖尿病周围血管病变; 踝肱指数
Keywords:
Type 2 diabetes mellitus; Diabetic peripheral vascular disease; Ankle brachial index
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2022.05.033
文献标志码:
A
摘要:
目的 探讨2型糖尿病（T2DM）患者周围血管病变（DPVD）相关危险因素及踝肱指数（ABI）的临床应用价值。方法 选取2020年7月-12月我院内分泌科门诊就诊的70例T2DM患者为研究对象，根据ABI值，将ABI≤0.9（存在DPVD）作为ABI降低组，ABI＞0.9（不存在DPVD）作为ABI正常组。比较两组临床资料及实验室指标，并采用二元Logistic回归分析DPVD的危险因素。结果 70例T2DM患者中28例患者ABI≤0.9，DPVD发病率为40.00%。ABI降低组年龄、病程、HbA1c、TG、LDL-C、UA、CREA水平均高于ABI正常组，FT3水平低于ABI正常组，差异有统计学意义（P＜0.05）；两组性别、TC、HDL-C、TSH、FT4水平比较，差异无统计学意义（P＞0.05）；二元Logistic回归分析显示，年龄、病程、HbA1c、TG、LDL-C、FT3、UA、CREA是DPVD的独立危险因素。结论 T2DM患者DPVD发生率较高，年龄、病程、HbA1c、TG、LDL-C、FT3、UA、CREA与DPVD密切相关。临床上应对病程较长、血糖控制欠佳的老年T2DM患者进行血脂、甲状腺功能、UA及CREA水平监测，早期预防DPVD；同时，可定期检测ABI，早期筛查DPVD，以期达到早预防、早诊断、早治疗的目的。
Abstract:
Objective To investigate the related risk factors of peripheral vascular disease (DPVD) and the clinical application value of ankle brachial index (ABI) in patients with type 2 diabetes mellitus (T2DM).Methods A total of 70 T2DM patients in the Outpatient Department of Endocrinology of our hospital from July to December 2020 were selected as the research object. According to the ABI value, ABI≤0.9 (with DPVD) was regarded as the ABI reduction group, and ABI>0.9 (without DPVD) was regarded as the ABI normal group. The clinical data and laboratory indexes of the two groups were compared, and the risk factors of DPVD were analyzed by binary logistic regression.Results Of the 70 T2DM patients, 28 patients were ABI less than 0.9, and the DPVD incidence rate was 40.00%. The age, course of disease, HbA1c, TG, LDL-C, UA and CREA levels in the ABI reduction group were higher than those in the ABI normal group, and the FT3 level was lower than that in the ABI normal group (P<0.05); there was no significant difference in gender, TC, HDL-C, TSH and FT4 between the two groups (P>0.05). Binary logistic analysis showed that age, course of disease, HbA1c, TG, LDL-C, FT3, UA and CREA were independent risk factors for DPVD.Conclusion The incidence of DPVD in T2DM patients is high. Age, course of disease, HbA1c, TG, LDL-C, FT3, UA and CREA are closely related to DPVD. Clinically, the blood lipid, thyroid function, UA and CREA levels of elderly T2DM patients with long course of disease and poor blood glucose control should be monitored to prevent DPVD in the early stage. At the same time, ABI can be detected regularly and DPVD can be screened early in order to achieve the purpose of early prevention, early diagnosis and early treatment.

参考文献/References:

[1]Ija B,Ana C.Diabetes and heart failure Notions from epidemiology including patterns in low-,middle-and high-income countries[J].Diabetes Research and Clinical Practice,2021(4):108822.[2]Ogurtsova K,Fernandes JR,Huang Y,et al.IDF Diabetes Atlas:Global estimates for the prevalence of diabetes for 2015 and 2040[J].Diabetes Res Clin Pract,2017,128(3):40-50.[3]潘爱平,靳晓萍.糖尿病患者自我管理行为及血糖控制情况的相关性研究[J].新疆医学,2014,44(11):127-129.[4]陈灏珠,钟南山,陆再英.内科学[M].第9版.北京:人民卫生出版社,2018:729-733.[5]Huysman F,Mathieu C.Diabetes and Peripheral Vascular Disease[J].Acta Chirurgica Belgica,2009,109(5):587-594.[6]Premalatha G,Ravikumar R,Sanjay R,et al.Comparison of colour duplex ultrasound and ankle-brachial pressure index measurements in peripheral vascular disease in type 2 diabetic patients with foot infections[J].J Assoc Physicians India,2002(50):1240-1244.[7]Ugwu E,Anyanwu A,Olamoyegun M.Ankle brachial index as a surrogate to vascular imaging in evaluation of peripheral artery disease in patients with type 2 diabetes[J].BMC Cardiovasc Disord,2021,21(1):10. [8]Alves-Cabratosa L,Comas-Cufí M,Ponjoan A,et al.Levels of ankle-brachial index and the risk of diabetes mellitus complicationss[J].BMJ Open Diabetes Res Care,2020,8(1):e000977.[9]Cardoso CRL,Melo JV,Salles GC,et al.Prognostic impact of the ankle-brachial index on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro Type 2 Diabetes Cohort Study[J].Diabetologia,2018,61(11):2266-2276.[10]张净,薛耀明.2型糖尿病踝肱指数异常相关危险因素分析及对糖尿病足的预测价值[J].中华内科杂志,2013,52(11):951-955.[11]王亚平,黄令一,曹杨,等.踝肱指数检测在糖尿病下肢周围血管病变中的应用价值[J].局解手术学杂志,2016,25(1):47-49.[12]丁毅,杨欣.青年糖尿病内皮祖细胞数量与颈动脉粥样硬化的相关性研究[J].华夏医学,2018,31(4):24-26.[13]王业青,张晓梅,董丽,等.雌二醇对视网膜缺血-再灌注损伤后基质细胞衍生因子-1表达的影响[J].眼科新进展,2017,37(3):215-219.[14]刘宗超,韦章超,刘勇,等.基质细胞衍生因子1对于血管内皮细胞增殖影响及其相关机制研究[J].中国修复重建外科杂志,2017,31(1):91-97.[15]殷琼洲,孙可欣,刘志科,等.2型糖尿病与血清基质细胞衍生因子-1水平的相关性[J].实用医学杂志,2017,33(17):2939-2942.[16]Magri CJ,Mintoff D,Camilleri L,et al.Relationship of Hyperglycaemia, Hypoglycaemia, and Glucose Variability to Atherosclerotic Disease in Type 2 Diabetes[J].J Diabetes Res,2018(2018):7464320.[17]赵新,李晓通,肖金凤,等.非肥胖2型糖尿病合并周围血管病患者血脂水平变化及意义[J].山东医药,2014,54(8):61-62.[18]Yuan D,Zhang C,Jia S,et al.Predictive value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio in long-term outcomes of euthyroid patients with three-vessel coronary artery disease[J].Nutr Metab Cardiovasc Dis,2021,31(2):579-586.[19]张赟贤.尿白蛋白/肌酐与2型糖尿病患者大血管病变的关系及其危险因素分析[D].石家庄:河北医科大学,2016.[20]张艳青,何友权.血清尿酸水平与2型糖尿病患者心血管疾病发病的相关性[J].中国急救复苏与灾害医学杂志,2020,15(3):291-294.[21]马静,赵立华,谢云.2型糖尿病合并高尿酸血症患者与空腹C肽和胰岛素抵抗的相关性研究[J].中国糖尿病杂志,2015,23(1):46-49.[22]施佳成,黄倩,沈艳明,等.不同血清尿酸水平与心血管疾病危险因素的相关性研究[J].江西医药,2020,55(8):984-988. [23]白慧华,周铸,邓楠.2型糖尿病患者发生血管并发症的危险因素分析[J].海南医学,2018,29(13):1802-1804.[24]杨菲飞,张聪,陈鑫,等.社区2型糖尿病患者踝肱指数影响因素分析[J].预防医学,2020,32(1):4-8.[25]李豫湘.2型糖尿病患者踝肱指数与微血管并发症的相关性分析[J].实用中西医结合临床,2018,18(11):74-75.

相似文献/References:

[1]黄德斌,章臻翊,章 婷,等.2型糖尿病患者亚临床甲状腺功能减退与白蛋白尿的关系研究[J].医学信息,2018,31(02):88.[doi:10.3969/j.issn.1006-1959.2018.02.030]
　HUANG De-bin,ZHANG Zhen-yi,ZHANG Ting,et al.Relationship between Subclinical Hypothyroidism and Albuminuria in Patients with Type 2 Diabetes Mellitus[J].Medical Information,2018,31(05):88.[doi:10.3969/j.issn.1006-1959.2018.02.030]
[2]邓婷婷,王亚洲,张 红.口福怡稻治疗2型糖尿病的临床效果研究[J].医学信息,2018,31(03):116.[doi:10.3969/j.issn.1006-1959.2018.03.039]
　DENG Ting-ting,WANG Ya-zhou,ZHANG Hong.Clinical Study on the Treatment of Type 2 Diabetes Mellitus with Kou Fuyi Dao[J].Medical Information,2018,31(05):116.[doi:10.3969/j.issn.1006-1959.2018.03.039]
[3]曹岚,侯瑞田,王福慧,等.Lp-PLA2血小板相关因子与2型糖尿病合并高血压病的 相关性研究[J].医学信息,2018,31(05):3.[doi:10.3969/j.issn.1006-1959.2018.05.002]
　CAO Lan,HOU Rui-tian,WANG Fu-hui,et al.Study on the Correlation between Lp-PLA2 Platelet-associated Factors and Type 2 Diabetes Mellitus Complicated with Hypertension[J].Medical Information,2018,31(05):3.[doi:10.3969/j.issn.1006-1959.2018.05.002]
[4]靳雪芹,邓正聪.代谢综合征与肿瘤关系的研究进展[J].医学信息,2018,31(05):35.[doi:10.3969/j.issn.1006-1959.2018.05.014]
　JIN Xue-qin,DENG Zheng-cong.Research Progress on the Relationship between Metabolic Syndrome and Tumor[J].Medical Information,2018,31(05):35.[doi:10.3969/j.issn.1006-1959.2018.05.014]
[5]刘 洪.地特胰岛素或甘精胰岛素联合使用口服药物治疗2型糖尿病疗效及对体重的影响分析[J].医学信息,2018,31(09):135.[doi:10.3969/j.issn.1006-1959.2018.09.042]
　LIU Hong.Effect of Insulin Detemir or Insulin Glargine Combined with Oral Medication on Type 2 Diabetes Mellitus and its Influence on Body Weight[J].Medical Information,2018,31(05):135.[doi:10.3969/j.issn.1006-1959.2018.09.042]
[6]刘静波,黄 萍,赵 静.应用微信平台对初发中青年2型糖尿病患者进行 健康管理模式的研究[J].医学信息,2018,31(14):98.[doi:10.3969/j.issn.1006-1959.2018.14.028]
　LIU Jing-bo,HUANG Ping,ZHAO Jing.Study on the Health Management Model of Young and Middle-aged Patients with Type 2 Diabetes Mellitus by WeChat Platform[J].Medical Information,2018,31(05):98.[doi:10.3969/j.issn.1006-1959.2018.14.028]
[7]丁 星,赵 畅,张海严,等.麦邦数据远程传输型血糖仪临床测量准确性的评价研究[J].医学信息,2018,31(15):64.[doi:10.3969/j.issn.1006-1959.2018.15.020]
　DING Xing,ZHAO Chang,ZHANG Hai-yan,et al.Evaluation of Accuracy of Clinical Measurement of Maibang Remote Data Transmission Glucometer[J].Medical Information,2018,31(05):64.[doi:10.3969/j.issn.1006-1959.2018.15.020]
[8]梁延洋,程艳娜,华柏慧,等.胃癌合并2型糖尿病术后血糖改善的临床观察[J].医学信息,2018,31(17):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
　LIANG Yan-yang,CHENG Yan-na,HUA Bai-hui,et al.Clinical Observation of Postoperative Blood Glucose Improvement in Patients with Gastric Cancer Complicated with Type 2 Diabetes Mellitus[J].Medical Information,2018,31(05):187.[doi:10.3969/j.issn.1006-1959.2018.17.061]
[9]刘小红.长效胰岛素联合口服降糖药治疗2型糖尿病的 疗效与安全性评价[J].医学信息,2018,31(18):121.[doi:10.3969/j.issn.1006-1959.2018.18.038]
　LIU Xiao-hong.Efficacy and Safety of Long Acting Insulin Combined with Oral Hypoglycemic Agents in Treatment of Type 2 Diabetes Mellitus[J].Medical Information,2018,31(05):121.[doi:10.3969/j.issn.1006-1959.2018.18.038]
[10]鲍 哲,杨升伟,柯赛赛,等.益生元对2型糖尿病患者糖脂代谢的影响[J].医学信息,2018,31(18):132.[doi:10.3969/j.issn.1006-1959.2018.18.042]
　BAO Zhe,YANG Sheng-wei,KE Sai-sai,et al.Effect of Prebiotics on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes mellitus[J].Medical Information,2018,31(05):132.[doi:10.3969/j.issn.1006-1959.2018.18.042]

更新日期/Last Update: 1900-01-01