[1]侯婷婷,刘尚全.PLR与2型糖尿病合并颈动脉粥样斑块患者的相关性[J].医学信息,2021,34(04):103-105,114.[doi:10.3969/j.issn.1006-1959.2021.04.027]
　HOU Ting-ting,LIU Shang-quan.The Correlation Between PLR and Type 2 Diabetes Mellitus with Carotid Atherosclerotic Plaque[J].Medical Information,2021,34(04):103-105,114.[doi:10.3969/j.issn.1006-1959.2021.04.027]
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PLR与2型糖尿病合并颈动脉粥样斑块患者的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
103-105,114
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
The Correlation Between PLR and Type 2 Diabetes Mellitus with Carotid Atherosclerotic Plaque
文章编号:
1006-1959（2021）04-0103-04
作者:
侯婷婷; 刘尚全
（安徽医科大学第三附属医院/合肥市第一人民医院内分泌科，安徽 合肥 230061）
Author(s):
HOU Ting-ting; LIU Shang-quan
(Department of Endocrinology,the Third Affiliated Hospital of Anhui Medical University/Hefei First People’s Hospital, Hefei 230061,Anhui,China)
关键词:
血小板与淋巴细胞比值; 2型糖尿病; 颈动脉斑块
Keywords:
Platelet to lymphocyte ratio; Type 2 diabetes mellitus; Carotid artery plaque
分类号:
R587.2；R543.4
DOI:
10.3969/j.issn.1006-1959.2021.04.027
文献标志码:
A
摘要:
目的 探讨血小板与淋巴细胞比值（PLR）与2型糖尿病合并颈动脉斑块患者的相关性。方法 选择2010年1月~2016年12月于安徽医科大学第三附属医院/合肥市第一人民医院内分泌科住院的2型糖尿病（T2DM）患者1853例，根据颈动脉多普勒超声结果，将所有患者分为单纯T2DM组852例和T2DM合并颈动脉斑块组1001例，比较两组性别、年龄、总胆红素、谷丙转氨酶、谷草转氨酶、尿素氮、血肌酐、血尿酸、白细胞计数、中性粒细胞、血小板计数、NLR、PLR等指标，分析PLR与T2DM患者发生颈动脉斑块的关系。结果 T2DM合并颈动脉斑块组年龄、病程、收缩压、尿素氮、血肌酐、血尿酸、低密度脂蛋白胆固醇、白细胞、中性粒细胞、NLR、PLR高于单纯T2DM组，而舒张压、总胆红素、谷丙转氨酶、甘油三酯、血红蛋白、空腹血糖、肾小球滤过率低于单纯T2DM组，差异有统计学意义（P＜0.05）；二元Logistic回归分析显示，年龄、病程、血红蛋白、中性粒细胞、PLR是T2DM合并颈动脉斑块的独立危险因素。结论 PLR是T2DM合并颈动脉斑块的独立危险因素，可能是预测颈动脉斑块发生的临床标志物。另外，应注意监测患者的血红蛋白和中性粒细胞水平，这对防治2型糖尿病患者颈动脉斑块的形成具有一定意义。
Abstract:
Objective To explore the correlation between platelet-to-lymphocyte ratio (PLR) and type 2 diabetes mellitus with carotid plaque.Methods 1853 patients with type 2 diabetes mellitus(T2DM) who were hospitalized in the Endocrinology Department of the Third Affiliated Hospital of Anhui Medical University Hefei First People’s Hospital from January 2010 to December 2016 were selected.According to the results of carotid artery Doppler ultrasound, all patients were divided into T2DM-only group of 852 cases and T2DM combined with carotid plaque group of 1001 cases.Compare the two groups of indicators such as gender, age, total bilirubin, alanine aminotransferase, aspartate aminotransferase, urea nitrogen, blood creatinine, blood uric acid, white blood cell count, neutrophil count, platelet count, NLR, PLR, etc.To analyze the relationship between PLR and carotid plaque in T2DM patients.Results The age, course of disease, systolic blood pressure, urea nitrogen, blood creatinine, blood uric acid, low-density lipoprotein cholesterol, white blood cells, neutrophils, NLR and PLR in the T2DM combined with carotid plaque group were higher than those in the T2DM group alone.The diastolic blood pressure, total bilirubin, alanine aminotransferase, triglyceride, hemoglobin, fasting blood glucose, and glomerular filtration rate were lower than those in the T2DM group alone, the difference was statistically significant (P<0.05);Binary Logistic regression analysis showed that age, course of disease, hemoglobin, neutrophils, and PLR were independent risk factors for T2DM combined with carotid plaque.Conclusion PLR is an independent risk factor for T2DM combined with carotid plaque, and may be a clinical marker for predicting the occurrence of carotid plaque.In addition, attention should be paid to monitoring the levels of hemoglobin and neutrophils in patients, which has certain significance in preventing and treating carotid plaque formation in patients with type 2 diabetes mellitus.

参考文献/References:

[1]Cho NH,Shaw JE,Karuranga S,et al.IDF Diabetes Atlas:Global estimates of diabetes prevalence for 2017 and projections for 2045[J].Diabetes Research&Clinical Practice,2018(138):271-281. [2]Roumeliotis A,Roumeliotis S,Panagoutsos S,et al.Carotid intima-media thickness is an independent predictor of all-cause mortality and cardiovascular morbidity in patients with diabetes mellitus type 2 and chronic kidney disease[J].Ren Fail,2019,41(1):131-138. [3]Kozakova M,Morizzo C,Goncalves I,et al.Cardiovascular organ damage in type 2 diabetes mellitus: The role of lipids and inflammation[J].Cardiovascular Diabetology,2019,18(1):61. [4]石群,胡晓峰,周熙琳,等.血小板/淋巴细胞比值在老年2型糖尿病患者肾功能损害及病情评估中的应用价值[J].现代生物医学进展,2020,20(8):1481-1484,1510. [5]朱亚丽,徐伟娜,何丽,等.NLR、PLR在2型糖尿病合并急性脑梗死患者中的临床意义[J].中风与神经疾病杂志,2019,36(10):936-938. [6]邹仲良,蔡素萍,袁凤波,等.血小板/淋巴细胞计数比值对2型糖尿病患者发生糖尿病视网膜病变的诊断价值研究[J].中国实用医药,2019,14(20):77-78. [7]谷光宇,郭剑超,卓娜,等.初诊2型糖尿病患者中性粒细胞/淋巴细胞、血小板/淋巴细胞、平均血小板体积与早期动脉粥样硬化的关系[J].中国医师杂志,2018,20(6):861-864. [8]陈灏珠,钟南山,陆再英.内科学[M].第8版.北京:人民卫生出版社,2013:739-740. [9]Schmidt AM.Highlighting Diabetes Mellitus:The Epidemic Continues[J].Arteriosclerosis Thrombosis&Vascular Biology,2018,38(1):e1. [10]Mealey BL,Rose LF.Diabetes mellitus and inflammatory periodontal diseases[J].Curr Opin Endocrinol Diabetes Obes,2008,15(2):135-141. [11]Fioranelli M,Bottaccioli AG,Bottaccioli F,et al.Stress and Inflammation in Coronary Artery Disease:A Review Psychoneuroendocrineimmunology-Based[J].Frontiers in Immunology,2018(9):2031. [12]Osadnik T,Wasilewski J,Lekston A,et al.The platelet-to-lymphocyte ratio as a predictor of all-cause mortality in patients with coronary artery disease undergoing elective percutaneous coronary intervention and stent implantation[J].Journal of the Saudi Heart Association,2015,27(3):144-151. [13]董荣静,石柔,董雪娥,等.中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值与2型糖尿病患者颈动脉粥样硬化的相关性[J].中华临床医师杂志(电子版),2017,11(2):179-182. [14]臧丽,付平,刘芳,等.胱抑素C在评价2型糖尿病患者颈动脉粥样硬化中的作用[J].四川大学学报(医学版),2012,43(6):882-887. [15]张彦霞,彭荣荣,乔成栋.2型糖尿病患者血小板/淋巴细胞与颈动脉斑块在不同年龄组相关性研究[J].医学研究杂志,2019,48(9):159-163. [16]Cowman J,Dunne E,Oglesby I,et al.Age-related changes in platelet function are more profound in women than in men[J].Scientific Reports,2015,5(1):12235. [17]Newman JD,Echagarruga CT,Ogando YM,et al.Hyperglycemia enhances arsenic-induced platelet and megakaryocyte activation[J].Journal of Translational Medicine,2017,15(1):55.

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更新日期/Last Update: 1900-01-01