[1]李桂华,曹本玥.PA、hs-CRP、ox-LDL及H-FABP与ACI患者神经功能缺损程度的关系[J].医学信息,2021,34(16):112-114.[doi:10.3969/j.issn.1006-1959.2021.16.030]
　LI Gui-hua,CAO Ben-yue.The Relationship Between PA,hs-CRP,ox-LDL,H-FABP and the Degree of Neurological Deficit in Patients with ACI[J].Medical Information,2021,34(16):112-114.[doi:10.3969/j.issn.1006-1959.2021.16.030]
点击复制

PA、hs-CRP、ox-LDL及H-FABP与ACI患者神经功能缺损程度的关系()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年16期
页码:
112-114
栏目:
论著
出版日期:
2021-08-15

文章信息/Info

Title:
The Relationship Between PA,hs-CRP,ox-LDL,H-FABP and the Degree of Neurological Deficit in Patients with ACI
文章编号:
1006-1959（2021）16-0112-03
作者:
李桂华; 曹本玥
（1.天津市西青医院神经内科，天津 300380； 2.天津市人民医院神经内科肌电图室，天津 300000）
Author(s):
LI Gui-hua; CAO Ben-yue
(1.Department of Neurology,Tianjin Xiqing Hospital,Tianjin 300380,China; 2.Department of Neurology,Electromyography Room,Tianjin People’s Hospital,Tianjin 300000,China)
关键词:
前白蛋白; 超敏C反应蛋白; 氧化型低密度脂蛋白; 心脏型脂肪酸结合蛋白; 急性脑梗死; 神经功能缺损
Keywords:
Prealbumin; High-sensitivity C-reactive protein; Oxidized low-density lipoprotein;  Cardiac fatty acid binding protein; Acute cerebral infarction; Neurological deficit
分类号:
R743
DOI:
10.3969/j.issn.1006-1959.2021.16.030
文献标志码:
A
摘要:
目的 探讨血清前白蛋白（PA）、超敏C反应蛋白（hs-CRP）、氧化型低密度脂蛋白（ox-LDL）及心脏型脂肪酸结合蛋白（H-FABP）与急性脑梗死（ACI）患者神经功能缺损程度的关系。方法 选取2019年1月~2020年3月我院ACI患者100例作为ACI组、100例非ACI的住院患者对照组，采用ELISA检测两组的PA、hs-CRP、ox-LDL及H-FABP水平，并按照神经功能缺损评分（NIHSS）进行分层分析。结果 ACI组hs-CRP、ox-LDL及H-FABP水平高于对照组，PA水平低于对照组（P＜0.05）；重度组hs-CRP、H-FABP水平高于中度组和对照组，PA水平低于中度组和对照组（P＜0.05）；中度组hs-CRP、H-FABP水平高于对照组，PA水平低于对照组（P＜0.05）；重度组和中度组的ox-LDL高于对照组（P＜0.05）；ACI患者hs-CRP、ox-LDL、H-FABP水平与NIHSS评分呈正相关关系（r=0.516、0.462、0.574，P＜0.05），PA水平与NIHSS评分呈显著的负相关关系（r=-0.381，P＜0.05）。结论 PA、hs-CRP、ox-LDL及H-FABP水平变化能在一定程度上反映ACI患者神经功能缺损程度，对于指导临床上ACI患者治疗及康复具有一定的价值。
Abstract:
Objective To investigate the relationship between serum prealbumin (PA), high-sensitivity C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), heart fatty acid binding protein (H-FABP) and acute cerebral infarction (ACI) The relationship between the degree of neurological impairment in patients.Methods A total of 100 ACI patients in our hospital from January 2019 to March 2020 were selected as the ACI group and the control group of 100 non-ACI inpatients.ELISA was used to detect the levels of PA, hs-CRP, ox-LDL and H-FABP in the two groups, and stratified analysis was performed according to the neurological deficit score (NIHSS).Results The levels of hs-CRP, ox-LDL and H-FABP in the ACI group were higher than those in the control group, and the PA level was lower than that in the control group (P＜0.05);The levels of hs-CRP and H-FABP in the severe group were higher than those in the moderate group and the control group, and the PA level was lower than the moderate group and the control group (P＜0.05);The levels of hs-CRP and H-FABP in the moderate group were higher than those of the control group, and the level of PA was lower than the control group (P＜0.05);The ox-LDL of the severe and moderate groups was higher than that of the control group (P＜0.05);The levels of hs-CRP, ox-LDL, and H-FABP in ACI patients were significantly positively correlated with NIHSS scores (r=0.516, 0.462, 0.574, P＜0.05),There was a significant negative correlation between PA level and NIHSS score (r=-0.381, P＜0.05).Conclusion The changes in the levels of PA, hs-CRP, ox-LDL and H-FABP can reflect the degree of neurological impairment in ACI patients to a certain extent, and have certain value in guiding the clinical treatment and rehabilitation of ACI patients.

参考文献/References:

[1]Wang R,Zeng J,Wang F,et al.Risk factors of hemorrhagic transformation after intravenous thrombolysis with rt-PA in acute cerebral infarction[J].QJM,2018,34(6):90-93. [2]黄剑.同型半胱氨酸及高敏C-反应蛋白检测在急性脑梗死患者中的应用[J].实用临床医药杂志,2014,18(E02):117-118. [3]潘庭荣,黄梅,潘丹丹,等.脑卒中患者Hcy、GFAP、BDNF和hs-CRP水平与血管性认知障碍相关性研究[J].东南大学学报(医学版),2018,37(4):648-652. [4]冯锦丽,王卫.急性脑梗死患者循环miR-124表达水平与脑梗死体积,神经功能缺损程度的关系及其诊断价值[J].卒中与神经疾病,2018,25(1):21-24,38. [5]徐军丽.血清Hcy及OX-LDL水平与急性脑梗死的相关性分析[J].中国实用医药,2015,10(8):39-40. [6]Su T,Lan C,Lee T,et al.Posttraumatic cerebral infarction after decompressive craniectomy for traumatic brain injury:incidence,risk factors and outcome[J].Turkish Neurosurgery,2017,34(6):103-105. [7]Wu Q,Qu J,Yin Y,et al.Morning hypertension is a risk factor of macrovascular events following cerebral infarction[J].Medicine,2018,97(34):2013-2016. [8]Li M,Wu J,Chen X,et al.Symptomatic and silent cerebral infarction following surgical clipping of unruptured intracranial aneurysms:incidence,risk factors,and clinical outcome[J].Neurosurgical Review,2018,41(2):675-682. [9]郑莹莹,陈涛,吴佳力,等.联合检测缺血性脑卒中患者血清Hcy和NSE水平与神经功能缺损程度的关系研究[J].中国实验诊断学,2018,22(1):1-3. [10]张艳秋,王会民,邵义泽.脑卒中患者营养风险筛查及营养评估的临床研究[J].中华老年心脑血管病杂志,2016,18(4):405-407. [11]田梁佳,孙丽,马秀银.血清超敏C反应蛋白水平在缺血性脑卒中诊断中的作用分析[J].中国临床医生杂志,2017,45(7):52-54. [12]柳丰慧,张可帅.血清白介素6、基质金属蛋白酶9、基质金属蛋白酶抑制剂1、超敏C反应蛋白及神经生长因子水平与急性脑梗死患者神经功能缺损程度的关系研究[J].实用心脑肺血管病杂志,2017,25(1):35-38. [13]庄献博,王未飞,单广振,等.青中年缺血性脑卒中患者血清抗心磷脂抗体免疫球蛋白G、白细胞介素-17、超敏C反应蛋白水平变化的意义[J].中华诊断学电子杂志,2017,5(1):51-54. [14]路小薇.急性脑梗死患者血清炎性因子及血流动力学变化及意义[J].海南医学院学报,2016,22(1):93-95.

相似文献/References:

[1]付云杰.超敏C反应蛋白、前清蛋白及降钙素原在重症肺炎患者中的变化及诊断的临床意义[J].医学信息,2018,31(24):84.[doi:10.3969/j.issn.1006-1959.2018.24.022]
　FU Yun-jie.Changes of Hypersensitive C-reactive Protein,Proalbumin and Procalcitonin in Patients with Severe Pneumonia and Its Clinical Significance[J].Medical Information,2018,31(16):84.[doi:10.3969/j.issn.1006-1959.2018.24.022]
[2]镡子鸣,叶怀阔,任长杰.超敏C反应蛋白及妊娠相关血浆蛋白A预测再发急性冠脉综合征的临床价值[J].医学信息,2019,32(08):173.[doi:10.3969/j.issn.1006-1959.2019.08.055]
　TAN Zi-ming,YE Huai-kuo,et al.Clinical Value of High-sensitivity C-reactive Protein and Pregnancy-associated Plasma Protein A in Predicting Recurrent Acute Coronary Syndrome[J].Medical Information,2019,32(16):173.[doi:10.3969/j.issn.1006-1959.2019.08.055]
[3]陈 敏,侯洪伟.肝切除术后肝功能失代偿的相关风险指标分析[J].医学信息,2019,32(15):83.[doi:10.3969/j.issn.1006-1959.2019.15.026]
　CHEN Min,HOU Hong-wei.Analysis of Risk Indicators Related to Liver Function Decompensation after Hepatectomy[J].Medical Information,2019,32(16):83.[doi:10.3969/j.issn.1006-1959.2019.15.026]
[4]颜俊文,颜小庚.脑梗死患者早期血清中Hs-CRP、HGMB1与梗死体积关系的研究[J].医学信息,2019,32(20):89.[doi:10.3969/j.issn.1006-1959.2019.20.024]
　YAN Jun-wen,YAN Xiao-geng.Relationship Between Serum Hs-CRP,HGMB1 and Infarct Volume in Patients with Cerebral Infarction[J].Medical Information,2019,32(16):89.[doi:10.3969/j.issn.1006-1959.2019.20.024]
[5]张艳果.冠心病患者血清超敏C反应蛋白、肌钙蛋白、血脂水平的变化及临床意义[J].医学信息,2020,33(02):167.[doi:10.3969/j.issn.1006-1959.2020.02.053]
　ZHANG Yan-guo.Changes and Clinical Significance of Serum High-sensitivity C-reactive Protein,Troponin and Blood Lipid Levels in Patients with Coronary Heart Disease[J].Medical Information,2020,33(16):167.[doi:10.3969/j.issn.1006-1959.2020.02.053]
[6]魏晓梅,王 淼,张晓伟,等.长期机采血小板捐献者PMP、超敏C反应蛋白、血小板参数与细菌培养结果分析[J].医学信息,2021,34(06):175.[doi:10.3969/j.issn.1006-1959.2021.06.047]
　WEI Xiao-mei,WANG Miao,ZHANG Xiao-wei,et al.Analysis of PMP,Hypersensitive C-reactive Protein,Platelet Parameters and Bacterial Culture Results in Long-term Mechanically Collected Platelets Donors[J].Medical Information,2021,34(16):175.[doi:10.3969/j.issn.1006-1959.2021.06.047]
[7]沈 仁,刘红艳,许 敏,等.脐血炎症标志物预测胎膜早破新生儿败血症的价值[J].医学信息,2021,34(20):105.[doi:10.3969/j.issn.1006-1959.2021.20.026]
　SHEN Ren,LIU Hong-yan,XU Min,et al.The Value of Umbilical Cord Blood Inflammatory Markers in Predicting Neonatal Sepsiswith Premature Rupture of Membranes[J].Medical Information,2021,34(16):105.[doi:10.3969/j.issn.1006-1959.2021.20.026]
[8]荣丽红,张恒春.血栓通联合依达拉奉治疗急性脑梗塞患者的效果[J].医学信息,2021,34(22):148.[doi:10.3969/j.issn.1006-1959.2021.22.046]
　RONG Li-hong,ZHANG Heng-chun.Effect of Xueshuantong Combined with Edaravone on Patients with Acute Cerebral Infarction[J].Medical Information,2021,34(16):148.[doi:10.3969/j.issn.1006-1959.2021.22.046]
[9]宋少娟,苏国华.血清总胆汁酸、胆碱酯酶和前白蛋白检测在肝病诊断中应用探析[J].医学信息,2021,34(23):9.[doi:10.3969/j.issn.1006-1959.2021.23.002]
　SONG Shao-juan,SU Guo-hua.Application of Serum Total Bile Acid, Cholinesterase and Prealbumin Detection in the Diagnosis of Liver Disease[J].Medical Information,2021,34(16):9.[doi:10.3969/j.issn.1006-1959.2021.23.002]
[10]陈艳男,徐 劲.脑梗死患者血清SAA、hs-CRP与颅内动脉粥样硬化狭窄程度的相关性[J].医学信息,2022,35(09):120.[doi:10.3969/j.issn.1006-1959.2022.09.030]
　CHEN Yan-nan,XU Jin.Correlation Between Serum SAA, hs-CRP and Intracranial Atherosclerotic Stenosis in Patients with Cerebral Infarction[J].Medical Information,2022,35(16):120.[doi:10.3969/j.issn.1006-1959.2022.09.030]

更新日期/Last Update: 1900-01-01